4KK7

Structure of EccB1 from the type VII (ESX-1) secretion system of Mycobacterium tuberculosis.

Summary for 4KK7

Entry DOI	10.2210/pdb4kk7/pdb
Descriptor	ESX-1 secretion system protein eccB1, NICKEL (II) ION, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (5 entities in total)
Functional Keywords	duf690, snm6, esx-1, protein secretion, protein transport
Biological source	Mycobacterium tuberculosis
Total number of polymer chains	1
Total formula weight	42278.50
Authors	Korotkov, K.V.,Evans, T.J. (deposition date: 2013-05-05, release date: 2013-06-19, Last modification date: 2024-11-06)
Primary citation	Wagner, J.M.,Chan, S.,Evans, T.J.,Kahng, S.,Kim, J.,Arbing, M.A.,Eisenberg, D.,Korotkov, K.V. Structures of EccB1 and EccD1 from the core complex of the mycobacterial ESX-1 type VII secretion system. Bmc Struct.Biol., 16:5-5, 2016 Cited by PubMed Abstract: The ESX-1 type VII secretion system is an important determinant of virulence in pathogenic mycobacteria, including Mycobacterium tuberculosis. This complicated molecular machine secretes folded proteins through the mycobacterial cell envelope to subvert the host immune response. Despite its important role in disease very little is known about the molecular architecture of the ESX-1 secretion system. PubMed: 26922638 DOI: 10.1186/s12900-016-0056-6 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.68 Å)

Structure validation