4KV2

Ubiquitin-like domain of the mycobacterium tuberculosis type VII secretion system protein ECCD1

Summary for 4KV2

• Entry DOI: 10.2210/pdb4kv2/pdb
• Related: 4KV3
• Descriptor: ESX-1 secretion system protein eccD1 (2 entities in total)
• Functional Keywords: esx-1, esx, snm4, ubiquitin, yukd, pf08817, membrane protein, protein secretion, protein transport
• Biological source: Mycobacterium tuberculosis
• Total number of polymer chains: 2
• Total formula weight: 19251.79

Authors

Korotkov, K.V.,Evans, T.J. (deposition date: 2013-05-22, release date: 2014-04-09, Last modification date: 2023-09-20)

Primary citation

Wagner, J.M.,Chan, S.,Evans, T.J.,Kahng, S.,Kim, J.,Arbing, M.A.,Eisenberg, D.,Korotkov, K.V.
Structures of EccB1 and EccD1 from the core complex of the mycobacterial ESX-1 type VII secretion system.
Bmc Struct.Biol., 16:5-5, 2016

PubMed Abstract: The ESX-1 type VII secretion system is an important determinant of virulence in pathogenic mycobacteria, including Mycobacterium tuberculosis. This complicated molecular machine secretes folded proteins through the mycobacterial cell envelope to subvert the host immune response. Despite its important role in disease very little is known about the molecular architecture of the ESX-1 secretion system.

PubMed: 26922638
DOI: 10.1186/s12900-016-0056-6

Experimental method

X-RAY DIFFRACTION (1.88 Å)