4KV3

Ubiquitin-like domain of the Mycobacterium tuberculosis type VII secretion system protein EccD1 as maltose-binding protein fusion

Summary for 4KV3

Entry DOI	10.2210/pdb4kv3/pdb
Related PRD ID	PRD_900001
Descriptor	Chimera fusion protein of ESX-1 secretion system protein eccD1 and Maltose-binding periplasmic protein, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose (3 entities in total)
Functional Keywords	esx-1, esx, snm4, ubiquitin, yukd, pf08817, membrane protein, protein secretion, mbp fusion, protein transport
Biological source	Escherichia coli More
Total number of polymer chains	2
Total formula weight	100745.79
Authors	Korotkov, K.V.,Evans, T.J. (deposition date: 2013-05-22, release date: 2014-04-09, Last modification date: 2023-09-20)
Primary citation	Wagner, J.M.,Chan, S.,Evans, T.J.,Kahng, S.,Kim, J.,Arbing, M.A.,Eisenberg, D.,Korotkov, K.V. Structures of EccB1 and EccD1 from the core complex of the mycobacterial ESX-1 type VII secretion system. Bmc Struct.Biol., 16:5-5, 2016 Cited by PubMed Abstract: The ESX-1 type VII secretion system is an important determinant of virulence in pathogenic mycobacteria, including Mycobacterium tuberculosis. This complicated molecular machine secretes folded proteins through the mycobacterial cell envelope to subvert the host immune response. Despite its important role in disease very little is known about the molecular architecture of the ESX-1 secretion system. PubMed: 26922638 DOI: 10.1186/s12900-016-0056-6 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation