7YXB

MHC-II dynamics are maintained in HLA-DR allotypes to ensure catalyzed peptide exchange

Summary for 7YXB

• Entry DOI: 10.2210/pdb7yxb/pdb
• Descriptor: HLA class II histocompatibility antigen, DR alpha chain, HLA class II histocompatibility antigen DR beta chain, CLIP peptide, ... (6 entities in total)
• Functional Keywords: hla-dr4, clip peptide, mhcii, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 96446.13

Authors

Roske, Y.,Abualrous, E.T.,Freund, C. (deposition date: 2022-02-15, release date: 2023-02-22, Last modification date: 2024-02-07)

• Primary citation: Abualrous, E.T.,Stolzenberg, S.,Sticht, J.,Wieczorek, M.,Roske, Y.,Gunther, M.,Dahn, S.,Boesen, B.B.,Calvo, M.M.,Biese, C.,Kuppler, F.,Medina-Garcia, A.,Alvaro-Benito, M.,Hofer, T.,Noe, F.,Freund, C.; MHC-II dynamics are maintained in HLA-DR allotypes to ensure catalyzed peptide exchange.; Nat.Chem.Biol., 19:1196-1204, 2023; PubMed: 37142807; DOI: 10.1038/s41589-023-01316-3

Experimental method

X-RAY DIFFRACTION (2.095 Å)