7YXB
MHC-II dynamics are maintained in HLA-DR allotypes to ensure catalyzed peptide exchange
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | HLA class II histocompatibility antigen, DR alpha chain | polymer | 192 | 22207.1 | 2 | UniProt (P01903) Pfam (PF00993) Pfam (PF07654) | Homo sapiens (human) | MHC class II antigen DRA |
| 2 | B, D (B, D) | HLA class II histocompatibility antigen DR beta chain | polymer | 198 | 23193.8 | 2 | UniProt (A0A1V1IGJ9) Pfam (PF00969) Pfam (PF07654) | Homo sapiens (human) | MHC class II antigen |
| 3 | E, F (G, H) | CLIP peptide | polymer | 20 | 2136.6 | 2 | UniProt (by SIFTS) (P04233) | Homo sapiens (human) | |
| 4 | G, H, I, J, K... (A, B, C, D, H) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 16 | Chemie (EDO) | |||
| 5 | R, W (C, G) | CITRATE ANION | non-polymer | 189.1 | 2 | Chemie (FLC) | |||
| 6 | AA, BA, CA, DA, Y... (C, D, G, H, A...) | water | water | 18.0 | 610 | Chemie (HOH) |
Sequence modifications
A, C: 1 - 191 (UniProt: P01903)
B, D: 2 - 198 (UniProt: A0A1V1IGJ9)
| PDB | External Database | Details |
|---|---|---|
| Val 192 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Val 199 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 95074.8 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 1371.3 | |
| All* | Total formula weight | 96446.1 |
