7YXB

MHC-II dynamics are maintained in HLA-DR allotypes to ensure catalyzed peptide exchange

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C	HLA class II histocompatibility antigen, DR alpha chain	polymer	192	22207.1	2	UniProt (P01903) Pfam (PF00993) Pfam (PF07654) In PDB	Homo sapiens (human)	MHC class II antigen DRA
2	B, D	HLA class II histocompatibility antigen DR beta chain	polymer	198	23193.8	2	UniProt (A0A1V1IGJ9) Pfam (PF00969) Pfam (PF07654) In PDB	Homo sapiens (human)	MHC class II antigen
3	G, H	CLIP peptide	polymer	20	2136.6	2	UniProt (by SIFTS) (P04233) In PDB	Homo sapiens (human)
4	A, B, C, D, H	1,2-ETHANEDIOL	non-polymer		62.1	16	Chemie (EDO)
5	C, G	CITRATE ANION	non-polymer		189.1	2	Chemie (FLC)
6		water	water		18.0	610	Chemie (HOH)

Sequence modifications

A, C: 1 - 191 (UniProt: P01903)

PDB	External Database	Details
Val 192	-	expression tag

B, D: 2 - 198 (UniProt: A0A1V1IGJ9)

PDB	External Database	Details
Val 199	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	95074.8
Non-Polymers*	Number of molecules	18
	Total formula weight	1371.3
All*	Total formula weight	96446.1

*Water molecules are not included.