6YVH
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![BU of 6yvh by Molmil](/molmil-images/mine/6yvh) | CWC22-CWC27-EIF4A3 Complex | Descriptor: | Eukaryotic initiation factor 4A-III, Pre-mRNA-splicing factor CWC22 homolog, Spliceosome-associated protein CWC27 homolog | Authors: | Basquin, J, Busetto, V, LeHir, H, Conti, E. | Deposit date: | 2020-04-28 | Release date: | 2020-05-13 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3.19 Å) | Cite: | Structural and functional insights into CWC27/CWC22 heterodimer linking the exon junction complex to spliceosomes. Nucleic Acids Res., 48, 2020
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6FT6
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![BU of 6ft6 by Molmil](/molmil-images/mine/6ft6) | Structure of the Nop53 pre-60S particle bound to the exosome nuclear cofactors | Descriptor: | 25S ribosomal RNA, 5S ribosomal RNA, 60S ribosomal protein L11-A, ... | Authors: | Schuller, J.M, Falk, S, Conti, E. | Deposit date: | 2018-02-20 | Release date: | 2018-03-28 | Last modified: | 2019-12-11 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structure of the nuclear exosome captured on a maturing preribosome. Science, 360, 2018
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6FSZ
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![BU of 6fsz by Molmil](/molmil-images/mine/6fsz) | Structure of the nuclear RNA exosome | Descriptor: | ATP-dependent RNA helicase DOB1, Exosome complex component CSL4, Exosome complex component MTR3, ... | Authors: | Schuller, J.M, Falk, S, Conti, E. | Deposit date: | 2018-02-20 | Release date: | 2018-03-21 | Last modified: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (4.6 Å) | Cite: | Structure of the nuclear exosome captured on a maturing preribosome. Science, 360, 2018
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8QCB
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![BU of 8qcb by Molmil](/molmil-images/mine/8qcb) | CryoEM structure of a S. Cerevisiae Ski2387 complex in the open state | Descriptor: | Antiviral helicase SKI2, Antiviral protein SKI8, Superkiller protein 3, ... | Authors: | Keidel, A, Koegel, A, Reichelt, P, Kowalinski, E, Schaefer, I.B, Conti, E. | Deposit date: | 2023-08-25 | Release date: | 2023-11-08 | Last modified: | 2023-11-29 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Concerted structural rearrangements enable RNA channeling into the cytoplasmic Ski238-Ski7-exosome assembly. Mol.Cell, 83, 2023
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8QCA
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![BU of 8qca by Molmil](/molmil-images/mine/8qca) | CryoEM structure of a S. Cerevisiae Ski2387 complex in the closed state bound to RNA | Descriptor: | Antiviral helicase SKI2, Antiviral protein SKI8, RNA (5'-R(P*UP*UP*UP*U)-3'), ... | Authors: | Keidel, A, Koegel, A, Reichelt, P, Kowalinski, E, Schaefer, I.B, Conti, E. | Deposit date: | 2023-08-25 | Release date: | 2023-11-15 | Last modified: | 2023-11-29 | Method: | ELECTRON MICROSCOPY (2.84 Å) | Cite: | Concerted structural rearrangements enable RNA channeling into the cytoplasmic Ski238-Ski7-exosome assembly. Mol.Cell, 83, 2023
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8Q9T
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![BU of 8q9t by Molmil](/molmil-images/mine/8q9t) | CryoEM structure of a S. Cerevisiae Ski238 complex bound to RNA | Descriptor: | Antiviral helicase SKI2, Antiviral protein SKI8, RNA (5'-R(P*UP*UP*UP*U)-3'), ... | Authors: | Keidel, A, Koegel, A, Reichelt, P, Kowalinski, E, Schaefer, I.B, Conti, E. | Deposit date: | 2023-08-21 | Release date: | 2023-11-29 | Method: | ELECTRON MICROSCOPY (2.84 Å) | Cite: | Concerted structural rearrangements enable RNA channeling into the cytoplasmic Ski238-Ski7-exosome assembly. Mol.Cell, 83, 2023
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8QCF
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![BU of 8qcf by Molmil](/molmil-images/mine/8qcf) | yeast cytoplasmic exosome-Ski2 complex degrading a RNA substrate | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Antiviral helicase SKI2, Exosome complex component CSL4, ... | Authors: | Keidel, A, Koegel, A, Reichelt, P, Kowalinski, E, Schaefer, I.B, Conti, E. | Deposit date: | 2023-08-25 | Release date: | 2024-01-10 | Method: | ELECTRON MICROSCOPY (2.55 Å) | Cite: | Concerted structural rearrangements enable RNA channeling into the cytoplasmic Ski238-Ski7-exosome assembly. Mol.Cell, 83, 2023
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4W8V
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![BU of 4w8v by Molmil](/molmil-images/mine/4w8v) | |
4W8X
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![BU of 4w8x by Molmil](/molmil-images/mine/4w8x) | Crystal Structure of Cmr1 from Pyrococcus furiosus bound to a nucleotide | Descriptor: | CRISPR system Cmr subunit Cmr1-1, GUANOSINE-3'-MONOPHOSPHATE, PHOSPHATE ION | Authors: | Benda, C, Ebert, J, Baumgaertner, M, Conti, E. | Deposit date: | 2014-08-26 | Release date: | 2014-10-15 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural Model of a CRISPR RNA-Silencing Complex Reveals the RNA-Target Cleavage Activity in Cmr4. Mol.Cell, 56, 2014
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4W8Y
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![BU of 4w8y by Molmil](/molmil-images/mine/4w8y) | Structure of full length Cmr2 from Pyrococcus furiosus (Manganese bound form) | Descriptor: | CRISPR system Cmr subunit Cmr2, MANGANESE (II) ION, ZINC ION | Authors: | Benda, C, Ebert, J, Baumgaertner, M, Conti, E. | Deposit date: | 2014-08-26 | Release date: | 2014-10-15 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural Model of a CRISPR RNA-Silencing Complex Reveals the RNA-Target Cleavage Activity in Cmr4. Mol.Cell, 56, 2014
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4WFD
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![BU of 4wfd by Molmil](/molmil-images/mine/4wfd) | Structure of the Rrp6-Rrp47-Mtr4 interaction | Descriptor: | ATP-dependent RNA helicase DOB1, Exosome complex exonuclease RRP6, Exosome complex protein LRP1, ... | Authors: | Schuch, B, Conti, E. | Deposit date: | 2014-09-14 | Release date: | 2014-10-29 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | The exosome-binding factors Rrp6 and Rrp47 form a composite surface for recruiting the Mtr4 helicase. Embo J., 33, 2014
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2QFA
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![BU of 2qfa by Molmil](/molmil-images/mine/2qfa) | Crystal structure of a Survivin-Borealin-INCENP core complex | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Baculoviral IAP repeat-containing protein 5, Borealin, ... | Authors: | Jeyaprakash, A.A, Klein, U.R, Lindner, D, Ebert, J, Nigg, E.A, Conti, E. | Deposit date: | 2007-06-27 | Release date: | 2007-11-06 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Structure of a Survivin-Borealin-INCENP Core Complex Reveals How Chromosomal Passengers Travel Together. Cell(Cambridge,Mass.), 131, 2007
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7AQO
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![BU of 7aqo by Molmil](/molmil-images/mine/7aqo) | yeast THO-Sub2 complex dimer | Descriptor: | BJ4_G0025130.mRNA.1.CDS.1, EM14S01-3B_G0007820.mRNA.1.CDS.1, TEX1 isoform 1, ... | Authors: | Schuller, S.K, Schuller, J.M, Prabu, R.J, Baumgartner, M, Bonneau, F, basquin, J, Conti, E. | Deposit date: | 2020-10-22 | Release date: | 2020-12-02 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | Structural insights into the nucleic acid remodeling mechanisms of the yeast THO-Sub2 complex. Elife, 9, 2020
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7APX
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![BU of 7apx by Molmil](/molmil-images/mine/7apx) | yeast THO-Sub2 complex | Descriptor: | ATP-dependent RNA helicase SUB2, Protein TEX1, THO complex subunit 2,Tho2, ... | Authors: | Schuller, S.K, Schuller, J.M, Prabu, R.J, Baumgartner, M, Bonneau, F, basquin, J, Conti, E. | Deposit date: | 2020-10-20 | Release date: | 2020-12-02 | Last modified: | 2024-05-01 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural insights into the nucleic acid remodeling mechanisms of the yeast THO-Sub2 complex. Elife, 9, 2020
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7Z52
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![BU of 7z52 by Molmil](/molmil-images/mine/7z52) | Human NEXT dimer - focused reconstruction of the single MTR4 | Descriptor: | Exosome RNA helicase MTR4, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, RNA (5'-R(P*UP*UP*UP*UP*U)-3'), ... | Authors: | Gerlach, P, Lingaraju, M, Salerno-Kochan, A, Bonneau, F, Basquin, J, Conti, E. | Deposit date: | 2022-03-07 | Release date: | 2022-06-22 | Last modified: | 2022-07-20 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structure and regulation of the nuclear exosome targeting complex guides RNA substrates to the exosome. Mol.Cell, 82, 2022
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7Z4Z
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![BU of 7z4z by Molmil](/molmil-images/mine/7z4z) | Human NEXT dimer - focused reconstruction of the dimerization module | Descriptor: | Exosome RNA helicase MTR4, Zinc finger CCHC domain-containing protein 8 | Authors: | Gerlach, P, Lingaraju, M, Salerno-Kochan, A, Bonneau, F, Basquin, J, Conti, E. | Deposit date: | 2022-03-06 | Release date: | 2022-06-22 | Last modified: | 2022-07-20 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structure and regulation of the nuclear exosome targeting complex guides RNA substrates to the exosome. Mol.Cell, 82, 2022
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7Z4Y
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![BU of 7z4y by Molmil](/molmil-images/mine/7z4y) | Human NEXT dimer - overall reconstruction of the core complex | Descriptor: | Exosome RNA helicase MTR4, Zinc finger CCHC domain-containing protein 8 | Authors: | Gerlach, P, Lingaraju, M, Salerno-Kochan, A, Bonneau, F, Basquin, J, Conti, E. | Deposit date: | 2022-03-06 | Release date: | 2022-06-22 | Last modified: | 2022-07-20 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | Structure and regulation of the nuclear exosome targeting complex guides RNA substrates to the exosome. Mol.Cell, 82, 2022
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6SYT
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![BU of 6syt by Molmil](/molmil-images/mine/6syt) | Structure of the SMG1-SMG8-SMG9 complex | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, MAGNESIUM ION, ... | Authors: | Gat, Y, Schuller, J.M, Conti, E. | Deposit date: | 2019-10-01 | Release date: | 2019-12-11 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (3.45 Å) | Cite: | InsP6binding to PIKK kinases revealed by the cryo-EM structure of an SMG1-SMG8-SMG9 complex. Nat.Struct.Mol.Biol., 26, 2019
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3FHC
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![BU of 3fhc by Molmil](/molmil-images/mine/3fhc) | Crystal structure of human Dbp5 in complex with Nup214 | Descriptor: | ATP-dependent RNA helicase DDX19B, Nuclear pore complex protein Nup214 | Authors: | von Moeller, H, Conti, E. | Deposit date: | 2008-12-09 | Release date: | 2009-02-17 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | The mRNA export protein DBP5 binds RNA and the cytoplasmic nucleoporin NUP214 in a mutually exclusive manner Nat.Struct.Mol.Biol., 16, 2009
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5JNB
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![BU of 5jnb by Molmil](/molmil-images/mine/5jnb) | structure of GLD-2/RNP-8 complex | Descriptor: | 1,2-ETHANEDIOL, MAGNESIUM ION, Poly(A) RNA polymerase gld-2, ... | Authors: | Nakel, K, Bonneau, F, Basquin, C, Eckmann, C.R, Conti, E. | Deposit date: | 2016-04-29 | Release date: | 2016-06-22 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.486 Å) | Cite: | Structural basis for the antagonistic roles of RNP-8 and GLD-3 in GLD-2 poly(A)-polymerase activity. Rna, 22, 2016
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6Z3R
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![BU of 6z3r by Molmil](/molmil-images/mine/6z3r) | Structure of SMG1-8-9 kinase complex bound to UPF1-LSQ | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, MAGNESIUM ION, ... | Authors: | Langer, L.M, Gat, Y, Conti, E. | Deposit date: | 2020-05-21 | Release date: | 2020-06-24 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (2.97 Å) | Cite: | Structure of substrate-bound SMG1-8-9 kinase complex reveals molecular basis for phosphorylation specificity. Elife, 9, 2020
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3FHT
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![BU of 3fht by Molmil](/molmil-images/mine/3fht) | |
3IBV
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![BU of 3ibv by Molmil](/molmil-images/mine/3ibv) | Karyopherin cytosolic state | Descriptor: | CALCIUM ION, Exportin-T | Authors: | Cook, A.G, Fukuhara, N, Jinek, M, Conti, E. | Deposit date: | 2009-07-17 | Release date: | 2009-08-25 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structures of the tRNA export factor in the nuclear and cytosolic states Nature, 461, 2009
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3ICQ
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![BU of 3icq by Molmil](/molmil-images/mine/3icq) | Karyopherin nuclear state | Descriptor: | Exportin-T, GTP-binding nuclear protein GSP1/CNR1, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Cook, A.G, Fukuhara, N, Jinek, M, Conti, E. | Deposit date: | 2009-07-18 | Release date: | 2009-08-25 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structures of the tRNA export factor in the nuclear and cytosolic states Nature, 461, 2009
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4ZKE
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![BU of 4zke by Molmil](/molmil-images/mine/4zke) | |