7Z4Y

Human NEXT dimer - overall reconstruction of the core complex

Summary for 7Z4Y

Entry DOI	10.2210/pdb7z4y/pdb
EMDB information	14510
Descriptor	Zinc finger CCHC domain-containing protein 8, Exosome RNA helicase MTR4 (2 entities in total)
Functional Keywords	helicase, atpase, rna degradation, exosome, rna binding protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	4
Total formula weight	305982.06
Authors	Gerlach, P.,Lingaraju, M.,Salerno-Kochan, A.,Bonneau, F.,Basquin, J.,Conti, E. (deposition date: 2022-03-06, release date: 2022-06-22, Last modification date: 2022-07-20)
Primary citation	Gerlach, P.,Garland, W.,Lingaraju, M.,Salerno-Kochan, A.,Bonneau, F.,Basquin, J.,Jensen, T.H.,Conti, E. Structure and regulation of the nuclear exosome targeting complex guides RNA substrates to the exosome. Mol.Cell, 82:2505-, 2022 Cited by PubMed: 35688157 DOI: 10.1016/j.molcel.2022.04.011 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (4.5 Å)

Structure validation