7Z4Y

Human NEXT dimer - overall reconstruction of the core complex

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, C	Zinc finger CCHC domain-containing protein 8	polymer	301	34669.0	2	UniProt (Q6NZY4) Pfam (PF00098) Pfam (PF04046) In PDB	Homo sapiens (human)	TRAMP-like complex RNA-binding factor ZCCHC8
2	B, D	Exosome RNA helicase MTR4	polymer	1046	118322.1	2	UniProt (P42285) Pfam (PF00270) Pfam (PF00271) Pfam (PF21408) Pfam (PF13234) Pfam (PF08148) In PDB	Homo sapiens (human)	ATP-dependent RNA helicase DOB1,ATP-dependent RNA helicase SKIV2L2,Superkiller viralicidic activity 2-like 2,TRAMP-like complex helicase

Sequence modifications

A, C: 41 - 337 (UniProt: Q6NZY4)

PDB	External Database	Details
Gly 37	-	expression tag
Pro 38	-	expression tag
Asp 39	-	expression tag
Ser 40	-	expression tag

B, D: 1 - 1042 (UniProt: P42285)

PDB	External Database	Details
Gly -3	-	expression tag
Pro -2	-	expression tag
Asp -1	-	expression tag
Ser 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	305982.1
All*	Total formula weight	305982.1

*Water molecules are not included.