6XG5
 
 | | X-ray structure of Escherichia coli dihydrofolate reductase in complex with trimethoprim | | Descriptor: | CHLORIDE ION, Dihydrofolate reductase, GLYCEROL, ... | | Authors: | Gaszek, I.K, Manna, M.S, Borek, D, Toprak, E. | | Deposit date: | 2020-06-16 | | Release date: | 2021-03-24 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | A trimethoprim derivative impedes antibiotic resistance evolution.
Nat Commun, 12, 2021
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6XG4
 | | X-ray structure of Escherichia coli dihydrofolate reductase L28R mutant in complex with trimethoprim | | Descriptor: | CHLORIDE ION, Dihydrofolate reductase, GLYCEROL, ... | | Authors: | Gaszek, I.K, Manna, M.S, Borek, D, Toprak, E. | | Deposit date: | 2020-06-16 | | Release date: | 2021-03-24 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | A trimethoprim derivative impedes antibiotic resistance evolution.
Nat Commun, 12, 2021
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1YSQ
 | | The crystal structure of transcriptional regulator YaiJ | | Descriptor: | HTH-type transcriptional regulator yiaJ, PHOSPHATE ION | | Authors: | Bochkarev, A, Lunin, V.V, Ezersky, A, Evdokimova, E, Skarina, T, Xu, X, Borek, D, Edwards, A.M, Joachimiak, A, Savchenko, A, Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2005-02-08 | | Release date: | 2005-03-22 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Structural study of effector binding specificity in IclR transcriptional regulators
To be Published
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6ROA
 | | Crystal structure of V57G mutant of human cystatin C | | Descriptor: | Cystatin-C | | Authors: | Orlikowska, M, Behrendt, I, Borek, D, Otwinowski, Z, Skowron, P, Szymanska, A. | | Deposit date: | 2019-05-10 | | Release date: | 2019-08-07 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.65 Å) | | Cite: | NMR and crystallographic structural studies of the extremely stable monomeric variant of human cystatin C with single amino acid substitution.
Febs J., 287, 2020
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2IW5
 | | Structural Basis for CoREST-Dependent Demethylation of Nucleosomes by the Human LSD1 Histone Demethylase | | Descriptor: | AMMONIUM ION, CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, ... | | Authors: | Yang, M, Gocke, C.B, Luo, X, Borek, D, Tomchick, D.R, Machius, M, Otwinowski, Z, Yu, H. | | Deposit date: | 2006-06-26 | | Release date: | 2006-08-09 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.57 Å) | | Cite: | Structural Basis for Corest-Dependent Demethylation of Nucleosomes by the Human Lsd1 Histone Demethylase
Mol.Cell, 23, 2006
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2OGG
 | | Structure of B. subtilis trehalose repressor (TreR) effector binding domain | | Descriptor: | GLYCEROL, SODIUM ION, SULFATE ION, ... | | Authors: | Rezacova, P, Krejcirikova, V, Borek, D, Moy, S.F, Joachimiak, A, Otwinowski, Z, Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2007-01-05 | | Release date: | 2007-02-06 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | The crystal structure of the effector-binding domain of the trehalose repressor TreR from Bacillus subtilis 168 reveals a unique quarternary assembly.
Proteins, 69, 2007
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7U5T
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7U5U
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7U5S
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6E59
 | | Crystal structure of the human NK1 tachykinin receptor | | Descriptor: | 1-(4-{[(2R,3S)-2-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}-3-(4-fluorophenyl)morpholin-4-yl]methyl}-1H-1,2,3-triazol-5-yl)-N,N-dimethylmethanamine, Substance-P receptor, GlgA glycogen synthase, ... | | Authors: | Yin, J, Clark, L, Chapman, K, Shao, Z, Borek, D, Xu, Q, Wang, J, Rosenbaum, D.M. | | Deposit date: | 2018-07-19 | | Release date: | 2018-12-12 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (3.4 Å) | | Cite: | Crystal structure of the human NK1tachykinin receptor.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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1R61
 | | The structure of predicted metal-dependent hydrolase from Bacillus stearothermophilus | | Descriptor: | SULFATE ION, ZINC ION, metal-dependent hydrolase | | Authors: | Maderova, J, Borek, D, Tomchick, D, Joachimiak, A, Collart, F, Otwinowski, Z, Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2003-10-14 | | Release date: | 2004-03-30 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | The structure of potential metal-dependent hydrolase with cyclase activity
To be Published
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2FCJ
 | | Structure of small TOPRIM domain protein from Bacillus stearothermophilus. | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLYCEROL, SULFATE ION, ... | | Authors: | Rezacova, P, Chen, Y, Borek, D, Collart, F, Joachimiak, A, Otwinowski, Z, Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2005-12-12 | | Release date: | 2006-01-24 | | Last modified: | 2012-10-24 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Crystal structure and putative function of small Toprim domain-containing protein from Bacillus stearothermophilus.
Proteins, 70, 2008
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2I5R
 | | Structure of small Toprim domain-containing protein from B. stearothermophilus in complex with Mg2+ | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLYCEROL, MAGNESIUM ION, ... | | Authors: | Rezacova, P, Borek, D, Otwinowski, Z, Joachimiak, A, Moy, S.F, Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2006-08-25 | | Release date: | 2007-07-03 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Crystal structure and putative function of small Toprim domain-containing protein from Bacillus stearothermophilus.
Proteins, 70, 2007
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3S67
 | | Crystal structure of V57P mutant of human cystatin C | | Descriptor: | ACETATE ION, CHLORIDE ION, Cystatin-C, ... | | Authors: | Orlikowska, M, Szymanska, A, Borek, D, Otwinowski, Z, Skowron, P, Jankowska, E. | | Deposit date: | 2011-05-25 | | Release date: | 2012-05-30 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.26 Å) | | Cite: | Structural characterization of V57D and V57P mutants of human cystatin C, an amyloidogenic protein.
Acta Crystallogr.,Sect.D, 69, 2013
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3SVA
 | | Crystal structure of V57D mutant of human cystatin C | | Descriptor: | ACETATE ION, Cystatin-C, DI(HYDROXYETHYL)ETHER | | Authors: | Orlikowska, M, Szymanska, A, Borek, D, Otwinowski, Z, Skowron, P, Jankowska, E. | | Deposit date: | 2011-07-12 | | Release date: | 2012-08-01 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (3.02 Å) | | Cite: | Structural characterization of V57D and V57P mutants of human cystatin C, an amyloidogenic protein.
Acta Crystallogr.,Sect.D, 69, 2013
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3TU3
 | | 1.92 Angstrom resolution crystal structure of the full-length SpcU in complex with full-length ExoU from the type III secretion system of Pseudomonas aeruginosa | | Descriptor: | ExoU, ExoU chaperone | | Authors: | Halavaty, A.S, Borek, D, Otwinowski, Z, Minasov, G, Veesenmeyer, J.L, Tyson, G, Shuvalova, L, Hauser, A.R, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | | Deposit date: | 2011-09-15 | | Release date: | 2012-05-23 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.92 Å) | | Cite: | Structure of the Type III Secretion Effector Protein ExoU in Complex with Its Chaperone SpcU.
Plos One, 7, 2012
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7KOX
 | | Alpha-7 nicotinic acetylcholine receptor bound to epibatidine and PNU-120596 in the activated state | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Noviello, C.M, Hibbs, R.E, Gharpure, A, Mukhtasimova, N, Baxter, L, Cabuco, R, Borek, D, Sine, S. | | Deposit date: | 2020-11-10 | | Release date: | 2021-03-17 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (2.7 Å) | | Cite: | Structure and gating mechanism of the alpha 7 nicotinic acetylcholine receptor.
Cell, 184, 2021
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7KOO
 | | Alpha-7 nicotinic acetylcholine receptor bound to alpha-bungarotoxin in a resting state | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-bungarotoxin isoform V31, ... | | Authors: | Noviello, C.M, Hibbs, R.E, Gharpure, A, Mukhtasimova, N, Cabuco, R, Baxter, L, Borek, D, Sine, S. | | Deposit date: | 2020-11-09 | | Release date: | 2021-03-17 | | Last modified: | 2024-11-06 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Structure and gating mechanism of the alpha 7 nicotinic acetylcholine receptor.
Cell, 184, 2021
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7KOQ
 | | Alpha-7 nicotinic acetylcholine receptor bound to epibatidine in a desensitized state | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | Authors: | Noviello, C.M, Hibbs, R.E, Gharpure, A, Mukhtasimova, N, Cabuco, R, Baxter, L, Borek, D, Sine, S. | | Deposit date: | 2020-11-09 | | Release date: | 2021-03-17 | | Last modified: | 2021-05-12 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Structure and gating mechanism of the alpha 7 nicotinic acetylcholine receptor.
Cell, 184, 2021
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6OTC
 | | Synthetic Fab bound to Marburg virus VP35 interferon inhibitory domain | | Descriptor: | CHLORIDE ION, GLYCEROL, Polymerase cofactor VP35, ... | | Authors: | Amatya, P, Chen, G, Borek, D, Sidhu, S.S, Leung, D.W. | | Deposit date: | 2019-05-02 | | Release date: | 2019-06-05 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Inhibition of Marburg Virus RNA Synthesis by a Synthetic Anti-VP35 Antibody.
Acs Infect Dis., 5, 2019
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3FWK
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3KRV
 | | The Structure Of Potential Metal-Dependent Hydrolase With Cyclase Activity | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, GLYCEROL, ... | | Authors: | Rakonjac, N, Rezacova, P, Borek, D, Collart, F, Joachimiak, A, Otwinowski, Z, Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2009-11-19 | | Release date: | 2010-01-05 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | The Structure Of Potential Metal-Dependent Hydrolase With Cyclase Activity
To be Published
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3IBS
 | | Crystal structure of conserved hypothetical protein BatB from Bacteroides thetaiotaomicron | | Descriptor: | CHLORIDE ION, GLYCEROL, MAGNESIUM ION, ... | | Authors: | Hattne, J, Bearden, J, Borek, D, Nakka, C, Sather, A, Joachimiak, A, Otwinowski, Z, Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2009-07-16 | | Release date: | 2009-08-25 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystal structure of conserved hypothetical protein BatB from Bacteroides thetaiotaomicron
To be Published
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1T0T
 | | Crystallographic structure of a putative chlorite dismutase | | Descriptor: | 3,6,9,12,15,18-HEXAOXAICOSANE-1,20-DIOL, APC35880, MAGNESIUM ION | | Authors: | Gilski, M, Borek, D, Chen, Y, Collart, F, Joachimiak, A, Otwinowski, Z, Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2004-04-12 | | Release date: | 2004-08-24 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Crystal Structure of APC35880 protein from Bacillus Stearothermophilus
To be Published
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3OAM
 | | Crystal structure of cytidylyltransferase from Vibrio cholerae | | Descriptor: | 3-deoxy-manno-octulosonate cytidylyltransferase, SODIUM ION | | Authors: | Hattne, J, Borek, D, Grimshaw, S, Nakka, C, Rostankowski, R, Otwinowski, Z, Center for Structural Genomics of Infectious Diseases (CSGID) | | Deposit date: | 2010-08-05 | | Release date: | 2010-09-22 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Crystal structure of cytidylyltransferase from Vibrio cholerae
TO BE PUBLISHED
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