7KOX

Alpha-7 nicotinic acetylcholine receptor bound to epibatidine and PNU-120596 in the activated state

Summary for 7KOX

• Entry DOI: 10.2210/pdb7kox/pdb
• EMDB information: 22983
• Descriptor: Neuronal acetylcholine receptor subunit alpha-7,Soluble cytochrome b562 fusion, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: cys-loop receptor, membrane protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 5
• Total formula weight: 324739.38

Authors

Noviello, C.M.,Hibbs, R.E.,Gharpure, A.,Mukhtasimova, N.,Baxter, L.,Cabuco, R.,Borek, D.,Sine, S. (deposition date: 2020-11-10, release date: 2021-03-17, Last modification date: 2021-05-12)

• Primary citation: Noviello, C.M.,Gharpure, A.,Mukhtasimova, N.,Cabuco, R.,Baxter, L.,Borek, D.,Sine, S.M.,Hibbs, R.E.; Structure and gating mechanism of the alpha 7 nicotinic acetylcholine receptor.; Cell, 184:2121-, 2021; PubMed: 33735609; DOI: 10.1016/j.cell.2021.02.049

Experimental method

ELECTRON MICROSCOPY (2.7 Å)