5JJR
| Dengue 3 NS5 protein with compound 29 | Descriptor: | 1,2-ETHANEDIOL, 5-[5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl]-4-methoxy-2-methyl-N-[(quinolin-8-yl)sulfonyl]benzamide, DI(HYDROXYETHYL)ETHER, ... | Authors: | Lescar, J, El Sahili, A. | Deposit date: | 2016-04-25 | Release date: | 2016-07-06 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling Plos Pathog., 12, 2016
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5K5M
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5JJS
| Dengue 3 NS5 protein with compound 27 | Descriptor: | 1,2-ETHANEDIOL, 5-[5-(3-hydroxyprop-1-yn-1-yl)thiophen-2-yl]-2,4-dimethoxy-N-{[(1R,3R)-3-methoxycyclohexyl]sulfonyl}benzamide, DI(HYDROXYETHYL)ETHER, ... | Authors: | Lescar, J, El Sahili, A. | Deposit date: | 2016-04-25 | Release date: | 2016-07-06 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Potent Allosteric Dengue Virus NS5 Polymerase Inhibitors: Mechanism of Action and Resistance Profiling Plos Pathog., 12, 2016
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4R8R
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4R8S
| Dengue serotype 3 methyltransferase bound to Sinefungin | Descriptor: | SINEFUNGIN, nonstructural protein NS5 | Authors: | Noble, C.G. | Deposit date: | 2014-09-02 | Release date: | 2014-10-15 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.48 Å) | Cite: | Crystal structure of dengue virus methyltransferase without S-adenosyl-L-methionine Antiviral Res., 111C, 2014
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3U1J
| Aprotinin bound to Dengue virus protease | Descriptor: | Pancreatic trypsin inhibitor, Serine protease NS3, Serine protease subunit NS2B | Authors: | Noble, C.G. | Deposit date: | 2011-09-30 | Release date: | 2011-11-09 | Last modified: | 2024-10-16 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Ligand-bound structures of the dengue virus protease reveal the active conformation J.Virol., 86, 2012
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3U1I
| Dengue virus protease covalently bound to a peptide | Descriptor: | SULFATE ION, Serine protease NS3, Serine protease subunit NS2B, ... | Authors: | Noble, C.G. | Deposit date: | 2011-09-29 | Release date: | 2011-11-09 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Ligand-bound structures of the dengue virus protease reveal the active conformation J.Virol., 86, 2012
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4IKA
| Crystal structure of EV71 3Dpol-VPg | Descriptor: | 3Dpol, NICKEL (II) ION, VPg | Authors: | Chen, C, Wang, Y.X, Lou, Z.Y. | Deposit date: | 2012-12-25 | Release date: | 2013-09-04 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal structure of enterovirus 71 RNA-dependent RNA polymerase complexed with its protein primer VPg: implication for a trans mechanism of VPg uridylylation J.Virol., 87, 2013
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3LKZ
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7L7F
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7L7D
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7L7E
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7L7K
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6C6K
| Structural basis for preferential recognition of cap 0 RNA by a human IFIT1-IFIT3 protein complex | Descriptor: | Interferon-induced protein with tetratricopeptide repeats 1, Interferon-induced protein with tetratricopeptide repeats 3, MAGNESIUM ION, ... | Authors: | Amarasinghe, G.K, Leung, D.W, Johnson, B, Xu, W. | Deposit date: | 2018-01-18 | Release date: | 2018-04-04 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.54 Å) | Cite: | Human IFIT3 Modulates IFIT1 RNA Binding Specificity and Protein Stability. Immunity, 48, 2018
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5F3Z
| Dengue serotype 3 RNA-dependent RNA polymerase bound to PC-79-SH52 | Descriptor: | 2-(4-methoxy-3-thiophen-2-yl-phenyl)ethanoic acid, Genome polyprotein, ZINC ION | Authors: | Noble, C.G. | Deposit date: | 2015-12-03 | Release date: | 2016-02-24 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | A Conserved Pocket in the Dengue Virus Polymerase Identified through Fragment-based Screening J.Biol.Chem., 291, 2016
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5F41
| DENGUE SEROTYPE 3 RNA-DEPENDENT RNA POLYMERASE BOUND TO FD-83-KI26 | Descriptor: | 2-(4-methoxy-3-thiophen-3-yl-phenyl)ethanoic acid, Genome polyprotein, ZINC ION | Authors: | Noble, C.G. | Deposit date: | 2015-12-03 | Release date: | 2016-02-24 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | A Conserved Pocket in the Dengue Virus Polymerase Identified through Fragment-based Screening J.Biol.Chem., 291, 2016
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5F3T
| Dengue serotype 3 RNA-dependent RNA polymerase bound to JF-31-MG46 | Descriptor: | 2-(4-methoxy-3-phenyl-phenyl)ethanoic acid, RNA-DEPENDENT RNA POLYMERASE, ZINC ION | Authors: | Noble, C.G. | Deposit date: | 2015-12-03 | Release date: | 2016-02-24 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | A Conserved Pocket in the Dengue Virus Polymerase Identified through Fragment-based Screening. J.Biol.Chem., 291, 2016
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5HN0
| Dengue serotype 3 RNA-dependent RNA polymerase bound to compound 4 | Descriptor: | (6-hydroxybiphenyl-3-yl)acetic acid, RNA-directed RNA polymerase NS5, ZINC ION | Authors: | Noble, C.G. | Deposit date: | 2016-01-17 | Release date: | 2016-03-30 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Discovery of Potent Non-Nucleoside Inhibitors of Dengue Viral RNA-Dependent RNA Polymerase from a Fragment Hit Using Structure-Based Drug Design. J.Med.Chem., 59, 2016
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8K6C
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8K68
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8K6D
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8K6A
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8K6B
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8K67
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7END
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