3U1J

Aprotinin bound to Dengue virus protease

Summary for 3U1J

• Entry DOI: 10.2210/pdb3u1j/pdb
• Related: 3U1I
• Descriptor: Serine protease subunit NS2B, Serine protease NS3, Pancreatic trypsin inhibitor, ... (4 entities in total)
• Functional Keywords: serine protease, bovine pancreatic trypsin inhibitor, er membrane, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Dengue virus 3 (DENV-3); More
• Cellular location: Capsid protein C: Virion (Potential). Peptide pr: Secreted (By similarity). Small envelope protein M: Virion membrane; Multi-pass membrane protein (By similarity). Envelope protein E: Virion membrane; Multi- pass membrane protein (By similarity). Non-structural protein 1: Secreted. Non-structural protein 2A-alpha: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Non-structural protein 2A: Host endoplasmic reticulum membrane; Multi-pass membrane protein (Potential). Serine protease subunit NS2B: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Serine protease NS3: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Non-structural protein 4A: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). Non-structural protein 4B: Host endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity). RNA-directed RNA polymerase NS5: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side (By similarity): Q5UB51 Q5UB51; Secreted: P00974
• Total number of polymer chains: 3
• Total formula weight: 32272.02

Authors

Noble, C.G. (deposition date: 2011-09-30, release date: 2011-11-09, Last modification date: 2023-11-01)

• Primary citation: Noble, C.G.,Seh, C.C.,Chao, A.T.,Shi, P.Y.; Ligand-bound structures of the dengue virus protease reveal the active conformation; J.Virol., 86:438-446, 2012; PubMed: 22031935; DOI: 10.1128/JVI.06225-11

Experimental method

X-RAY DIFFRACTION (1.8 Å)