5F41

DENGUE SEROTYPE 3 RNA-DEPENDENT RNA POLYMERASE BOUND TO FD-83-KI26

Summary for 5F41

Related5F3Z 5FST
DescriptorGenome polyprotein, ZINC ION, 2-(4-methoxy-3-thiophen-3-yl-phenyl)ethanoic acid, ... (4 entities in total)
Functional Keywordsinhibitor rdrp, dengue virus, transferase
Biological sourceDengue virus 3
Cellular locationVirion membrane ; Multi-pass membrane protein  Q6DLV0
Total number of polymer chains1
Total molecular weight74003.98
Authors
Noble, C.G. (deposition date: 2015-12-03, release date: 2016-02-24, Last modification date: 2016-06-08)
Primary citation
Noble, C.G.,Lim, S.P.,Arora, R.,Yokokawa, F.,Nilar, S.,Seh, C.C.,Wright, S.K.,Benson, T.E.,Smith, P.W.,Shi, P.Y.
A Conserved Pocket in the Dengue Virus Polymerase Identified through Fragment-based Screening
J.Biol.Chem., 291:8541-8548, 2016
PubMed: 26872970 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M115.710731
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2 Å)
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.23010.2%4.1%9.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution