4ZZ2
HUMAN GAR TRANSFORMYLASE IN COMPLEX WITH GAR AND (S)-2-({5-[3-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-6-YL)-PROPYL]-THIOPHENE-3-CARBONYL}-AMINO)-PENTANEDIOIC ACID
Summary for 4ZZ2
Entry DOI | 10.2210/pdb4zz2/pdb |
Related | 1MEJ 1MEN 1MEO 1NJS 1RBM 1RBQ 1RBY 1RBZ 1RC0 1RC1 1ZLX 1ZLY 4EW2 4EW3 4ZYT 4ZYU 4ZYV 4ZYW 4ZYX 4ZYY 4ZYZ 4ZZ0 4ZZ1 4ZZ3 |
Descriptor | Trifunctional purine biosynthetic protein adenosine-3, GLYCINAMIDE RIBONUCLEOTIDE, (S)-2-({5-[3-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-6-yl)-propyl]-thiophene-3-carbonyl}-amino)-pentanedioic acid, ... (4 entities in total) |
Functional Keywords | gar transformylase, antifolate, transferase-transferase inhibitor complex, structural genomics, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 23541.76 |
Authors | Deis, S.M.,Dann III, C.E. (deposition date: 2015-05-22, release date: 2015-12-16, Last modification date: 2023-09-27) |
Primary citation | Wang, L.,Wallace, A.,Raghavan, S.,Deis, S.M.,Wilson, M.R.,Yang, S.,Polin, L.,White, K.,Kushner, J.,Orr, S.,George, C.,O'Connor, C.,Hou, Z.,Mitchell-Ryan, S.,Dann, C.E.,Matherly, L.H.,Gangjee, A. 6-Substituted Pyrrolo[2,3-d]pyrimidine Thienoyl Regioisomers as Targeted Antifolates for Folate Receptor alpha and the Proton-Coupled Folate Transporter in Human Tumors. J.Med.Chem., 58:6938-6959, 2015 Cited by PubMed: 26317331DOI: 10.1021/acs.jmedchem.5b00801 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.451 Å) |
Structure validation
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