4EW3
The structure of human glycinamide ribonucleotide transformylase in complex with 10R-methylthio-DDATHF.
Summary for 4EW3
| Entry DOI | 10.2210/pdb4ew3/pdb |
| Related | 1NJS 4EW1 4EW2 |
| Descriptor | Trifunctional purine biosynthetic protein adenosine-3, PHOSPHATE ION, SULFATE ION, ... (5 entities in total) |
| Functional Keywords | transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Homo sapiens (human) |
| Total number of polymer chains | 1 |
| Total formula weight | 23443.57 |
| Authors | Connelly, S.,DeMartino, K.,Boger, D.L.,Wilson, I.A. (deposition date: 2012-04-26, release date: 2013-07-31, Last modification date: 2023-09-13) |
| Primary citation | Connelly, S.,Demartino, J.K.,Boger, D.L.,Wilson, I.A. Biological and Structural Evaluation of 10R- and 10S-Methylthio-DDACTHF Reveals a New Role for Sulfur in Inhibition of Glycinamide Ribonucleotide Transformylase. Biochemistry, 52:5133-5144, 2013 Cited by PubMed: 23869564DOI: 10.1021/bi4005182 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.702 Å) |
Structure validation
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