4EW3

The structure of human glycinamide ribonucleotide transformylase in complex with 10R-methylthio-DDATHF.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Trifunctional purine biosynthetic protein adenosine-3	polymer	209	22678.9	1	UniProt (P22102) Pfam (PF00551) In PDB	Homo sapiens (human)	Phosphoribosylamine--glycine ligase, Glycinamide ribonucleotide synthetase, GARS, Phosphoribosylglycinamide synthetase, Phosphoribosylformylglycinamidine cyclo-ligase, AIR synthase, AIRS, Phosphoribosyl-aminoimidazole synthetase, Phosphoribosylglycinamide formyltransferase, 5'-phosphoribosylglycinamide transformylase, GAR transformylase, GART
2	A	PHOSPHATE ION	non-polymer		95.0	1	Chemie (PO4)
3	A	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
4	A	N-({4-[(1R)-4-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-1-(methylsulfanyl)butyl]phenyl}carbonyl)-L-glutamic acid	non-polymer		477.5	1	Chemie (DXZ)
5		water	water		18.0	167	Chemie (HOH)

Sequence modifications

A: 1 - 203 (UniProt: P22102)

PDB	External Database	Details
His 204	-	expression tag
His 205	-	expression tag
His 206	-	expression tag
His 207	-	expression tag
His 208	-	expression tag
His 209	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	22678.9
Non-Polymers*	Number of molecules	4
	Total formula weight	764.6
All*	Total formula weight	23443.6

*Water molecules are not included.