4ZZ2
HUMAN GAR TRANSFORMYLASE IN COMPLEX WITH GAR AND (S)-2-({5-[3-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-6-YL)-PROPYL]-THIOPHENE-3-CARBONYL}-AMINO)-PENTANEDIOIC ACID
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | binding site for residue GAR A 1101 |
| Chain | Residue |
| A | THR817 |
| A | GLU980 |
| A | 3YG1102 |
| A | HOH1223 |
| A | HOH1234 |
| A | HOH1241 |
| A | HOH1251 |
| A | HOH1263 |
| A | HOH1298 |
| A | HOH1317 |
| A | HOH1341 |
| A | GLY818 |
| A | SER819 |
| A | ASN820 |
| A | GLY894 |
| A | MET896 |
| A | ILE914 |
| A | PRO916 |
| A | LYS977 |
| site_id | AC2 |
| Number of Residues | 20 |
| Details | binding site for residue 3YG A 1102 |
| Chain | Residue |
| A | ARG871 |
| A | PHE895 |
| A | MET896 |
| A | ARG897 |
| A | ILE898 |
| A | LEU899 |
| A | VAL904 |
| A | GLY924 |
| A | SER925 |
| A | HIS944 |
| A | VAL946 |
| A | ALA947 |
| A | GLU948 |
| A | VAL950 |
| A | ASP951 |
| A | GAR1101 |
| A | HOH1213 |
| A | HOH1224 |
| A | HOH1336 |
| A | HOH1397 |
Functional Information from PROSITE/UniProt
| site_id | PS00373 |
| Number of Residues | 24 |
| Details | GART Phosphoribosylglycinamide formyltransferase active site. GcTVhFVaEdVDaGqiIlqeavpV |
| Chain | Residue | Details |
| A | GLY940-VAL963 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"P08179","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 5 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12450384","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16026156","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1MEN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZLY","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12755606","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1NJS","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 7 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12755606","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"16026156","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"1NJS","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ZLY","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Site: {"description":"Raises pKa of active site His","evidences":[{"source":"UniProtKB","id":"P08179","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
