4BAY

Phosphomimetic mutant of LSD1-8a splicing variant in complex with CoREST

4BAY の概要

• エントリーDOI: 10.2210/pdb4bay/pdb
• 関連するPDBエントリー: 2COM 2H94 2IW5 2UXN 2UXX 2V1D 2X0L 2XAF 2XAG 2XAH 2XAJ 2XAQ 2XAS 2Y48
• 分子名称: LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 1, FLAVIN-ADENINE DINUCLEOTIDE, ... (4 entities in total)
• 機能のキーワード: oxidoreductase, demethylase splicing chromatin
• 由来する生物種: HOMO SAPIENS (HUMAN); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 92323.09

構造登録者

Toffolo, E.,Paganini, L.,Rusconi, F.,Tortorici, M.,Pilotto, S.,Verpelli, C.,Tedeschi, G.,Maffioli, E.,Sala, C.,Mattevi, A.,Battaglioli, E. (登録日: 2012-09-17, 公開日: 2013-11-27, 最終更新日: 2023-12-20)

• 主引用文献: Toffolo, E.,Rusconi, F.,Paganini, L.,Tortorici, M.,Pilotto, S.,Heise, C.,Verpelli, C.,Tedeschi, G.,Maffioli, E.,Sala, C.,Mattevi, A.,Battaglioli, E.; Phosphorylation of Neuronal Lysine-Specific Demethylase 1Lsd1/Kdm1A Impairs Transcriptional Repression by Regulating Interaction with Corest and Histone Deacetylases Hdac1/2.; J.Neurochem., 128:616-, 2014; PubMed: 24111946; DOI: 10.1111/JNC.12457

実験手法

X-RAY DIFFRACTION (3.1 Å)