4BAY
Phosphomimetic mutant of LSD1-8a splicing variant in complex with CoREST
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A | polymer | 686 | 76220.1 | 1 | UniProt (O60341) Pfam (PF04433) Pfam (PF01593) | HOMO SAPIENS (HUMAN) | BRAF35-HDAC COMPLEX PROTEIN BHC110, FLAVIN-CONTAINING AMINE OXIDASE DOMAIN-CONTAINING PROTEIN 2, LSD1 |
| 2 | B (B) | REST COREPRESSOR 1 | polymer | 133 | 15317.4 | 1 | UniProt (Q9UKL0) Pfam (PF20878) Pfam (PF00249) | HOMO SAPIENS (HUMAN) | PROTEIN COREST |
| 3 | C (A) | FLAVIN-ADENINE DINUCLEOTIDE | non-polymer | 785.5 | 1 | Chemie (FAD) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 3 | Chemie (HOH) |
Sequence modifications
A: 172 - 852 (UniProt: O60341)
| PDB | External Database | Details |
|---|---|---|
| Pro 171 | - | expression tag |
| Asp 369 | Thr 391 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 91537.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 785.5 | |
| All* | Total formula weight | 92323.1 |
