2Y48

Crystal structure of LSD1-CoREST in complex with a N-terminal SNAIL peptide

Summary for 2Y48

Related2X0L 2UXX 2XAQ 2XAF 2IW5 2COM 2XAJ 2XAG 2V1D 2XAH 2UXN 2XAS 2H94
DescriptorLYSINE-SPECIFIC DEMETHYLASE 1A, REST COREPRESSOR 1, ZINC FINGER PROTEIN SNAI1, ... (4 entities in total)
Functional Keywordsoxidoreductase, flavin, histone, repressor, transcription regulation, chromatin, nuclear protein
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationNucleus O60341 Q9UKL0 O95863
Total number of polymer chains3
Total molecular weight104702.5
Authors
Baron, R.,Binda, C.,Tortorici, M.,McCammon, J.A.,Mattevi, A. (deposition date: 2011-01-05, release date: 2011-02-16, Last modification date: 2011-07-13)
Primary citation
Baron, R.,Binda, C.,Tortorici, M.,Mccammon, J.A.,Mattevi, A.
Molecular Mimicry and Ligand Recognition in Binding and Catalysis by the Histone Demethylase Lsd1-Corest Complex.
Structure, 19:212-, 2011
PubMed: 21300290 (PDB entries with the same primary citation)
DOI: 10.1016/J.STR.2011.01.001
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.24592.1%9.3%0.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report