2X0L

Crystal structure of a neuro-specific splicing variant of human histone lysine demethylase LSD1.

Summary for 2X0L

Related2UXX 2IW5 2V1D 2UXN 2COM 2H94
DescriptorLYSINE-SPECIFIC HISTONE DEMETHYLASE 1, REST COREPRESSOR 1, HISTONE H3 PEPTIDE, ... (4 entities in total)
Functional Keywordsrepressor complex, chromatin remodelling, amine oxidase, transcription, host-virus interaction, transcription regulation, phosphoprotein, oxidoreductase, nuclear protein, chromatin regulator, developmental protein
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationNucleus  O60341 Q9UKL0
Chromosome . Nucleus  Q5TEC6
Total number of polymer chains3
Total molecular weight99491.86
Authors
Zibetti, C.,Adamo, A.,Binda, C.,Forneris, F.,Verpelli, C.,Ginelli, E.,Mattevi, A.,Sala, C.,Battaglioli, E. (deposition date: 2009-12-15, release date: 2010-03-02, Last modification date: 2016-12-14)
Primary citation
Zibetti, C.,Adamo, A.,Binda, C.,Forneris, F.,Toffolo, E.,Verpelli, C.,Ginelli, E.,Mattevi, A.,Sala, C.,Battaglioli, E.
Alternative Splicing of the Histone Demethylase Lsd1/Kdm1 Contributes to the Modulation of Neurite Morphogenesis in the Mammalian Nervous System.
J.Neurosci., 30:2521-, 2010
PubMed: 20164337 (PDB entries with the same primary citation)
DOI: 10.1523/JNEUROSCI.5500-09.2010
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.246122.3%10.5%1.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report