2X0L
Crystal structure of a neuro-specific splicing variant of human histone lysine demethylase LSD1.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | LYSINE-SPECIFIC HISTONE DEMETHYLASE 1 | polymer | 734 | 81723.9 | 1 | UniProt (O60341) Pfam (PF04433) Pfam (PF01593) | HOMO SAPIENS (HUMAN) | FLAVIN-CONTAINING AMINE OXIDASE DOMAIN-CONTAINING PROTEIN 2, BRAF35-HDAC COMPLEX PROTEIN BHC110 |
| 2 | B (B) | REST COREPRESSOR 1 | polymer | 133 | 15317.4 | 1 | UniProt (Q9UKL0) Pfam (PF20878) Pfam (PF00249) | HOMO SAPIENS (HUMAN) | PROTEIN COREST, COREPRESSOR COREST |
| 3 | C (C) | HISTONE H3 PEPTIDE | polymer | 16 | 1664.9 | 1 | UniProt (Q5TEC6) UniProt (by SIFTS) (P68431) | HOMO SAPIENS | |
| 4 | D (A) | FLAVIN-ADENINE DINUCLEOTIDE | non-polymer | 785.5 | 1 | Chemie (FAD) |
Sequence modifications
A: 123 - 852 (UniProt: O60341)
C: 1 - 16 (UniProt: Q5TEC6)
| PDB | External Database | Details |
|---|---|---|
| Asp 369 | - | insertion |
| Thr 369 | - | insertion |
| Val 369 | - | insertion |
| Lys 369 | - | insertion |
| PDB | External Database | Details |
|---|---|---|
| Met 4 | Lys 5 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 98706.3 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 785.5 | |
| All* | Total formula weight | 99491.9 |
