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2X0L

Crystal structure of a neuro-specific splicing variant of human histone lysine demethylase LSD1.

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1ALYSINE-SPECIFIC HISTONE DEMETHYLASE 1polymer73481723.91UniProt (O60341)
Pfam (PF04433)
Pfam (PF01593)
In PDB
HOMO SAPIENS (HUMAN)FLAVIN-CONTAINING AMINE OXIDASE DOMAIN-CONTAINING PROTEIN 2, BRAF35-HDAC COMPLEX PROTEIN BHC110
2BREST COREPRESSOR 1polymer13315317.41UniProt (Q9UKL0)
Pfam (PF20878)
Pfam (PF00249)
In PDB
HOMO SAPIENS (HUMAN)PROTEIN COREST, COREPRESSOR COREST
3CHISTONE H3 PEPTIDEpolymer161664.91UniProt (Q5TEC6)
UniProt (by SIFTS) (P68431)
In PDB
HOMO SAPIENS
4AFLAVIN-ADENINE DINUCLEOTIDEnon-polymer785.51Chemie (FAD)
Sequence modifications
A: 123 - 852 (UniProt: O60341)
PDBExternal DatabaseDetails
Asp 369-insertion
Thr 369-insertion
Val 369-insertion
Lys 369-insertion
C: 1 - 16 (UniProt: Q5TEC6)
PDBExternal DatabaseDetails
Met 4Lys 5engineered mutation
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains3
Total formula weight98706.3
Non-Polymers*Number of molecules1
Total formula weight785.5
All*Total formula weight99491.9
*Water molecules are not included.

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PDB entries from 2024-09-18

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