2XAG

Crystal structure of LSD1-CoREST in complex with para-bromo-(-)-trans- 2-phenylcyclopropyl-1-amine

Summary for 2XAG

Related2XAJ 2X0L 2UXX 2IW5 2V1D 2UXN 2COM 2H94 2XAQ 2XAF 2XAH 2XAS
DescriptorLYSINE-SPECIFIC HISTONE DEMETHYLASE 1, REST COREPRESSOR 1, FLAVIN-ADENINE DINUCLEOTIDE, ... (4 entities in total)
Functional Keywordsamine oxidase, chromatin regulator, histone inhibitor binding, methylation, nucleosome core, oxidoreductase, oxidoreductase-repressor complex, chromatin remodelling, transcription
Biological sourceHOMO SAPIENS
Cellular locationNucleus O60341 Q9UKL0
Total number of polymer chains2
Total molecular weight147127.05
Authors
Primary citation
Binda, C.,Valente, S.,Romanenghi, M.,Pilotto, S.,Cirilli, R.,Karytinos, A.,Ciossani, G.,Botrugno, O.A.,Forneris, F.,Tardugno, M.,Edmondson, D.E.,Minucci, S.,Mattevi, A.,Mai, A.
Biochemical, Structural, and Biological Evaluation of Tranylcypromine Derivatives as Inhibitors of Histone Demethylases Lsd1 and Lsd2.
J.Am.Chem.Soc., 132:6827-, 2010
PubMed: 20415477 (PDB entries with the same primary citation)
DOI: 10.1021/JA101557K
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.1 Å)
NMR Information
?

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.243112.3%11.7%1.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report