4ASB

The structure of modified benzoquinone ansamycins bound to yeast N- terminal Hsp90

4ASB の概要

• エントリーDOI: 10.2210/pdb4asb/pdb
• 関連するPDBエントリー: 1A4H 1AH6 1AH8 1AM1 1AMW 1BGQ 1HK7 1US7 1USU 1USV 1ZW9 1ZWH 2AKP 2BRC 2BRE 2CG9 2CGE 2CGF 2IWS 2IWU 2IWX 2VW5 2VWC 2WEP 2WEQ 2WER 2XD6 2XX2 2XX4 2XX5 2YGA 2YGE 2YGF 4AS9 4ASA 4ASF 4ASG
• 分子名称: ATP-DEPENDENT MOLECULAR CHAPERONE HSP82, (4E,6E,8S,9R,10E,12R,13R,14S,16R)-19-{[2-(dimethylamino)ethyl]amino}-13-hydroxy-8,14-dimethoxy-4,10,12,16,21-pentamethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate (3 entities in total)
• 機能のキーワード: chaperone, inhibition, ansamycin
• 由来する生物種: SACCHAROMYCES CEREVISIAE (BAKER'S YEAST)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 25504.17

構造登録者

Roe, S.M.,Prodromou, C. (登録日: 2012-04-30, 公開日: 2013-04-03, 最終更新日: 2024-05-01)

• 主引用文献: Kitson, R.R.,Chang, C.H.,Xiong, R.,Williams, H.E.,Davis, A.L.,Lewis, W.,Dehn, D.L.,Siegel, D.,Roe, S.M.,Prodromou, C.,Ross, D.,Moody, C.J.; Synthesis of 19-substituted geldanamycins with altered conformations and their binding to heat shock protein Hsp90.; Nat Chem, 5:307-314, 2013; PubMed: 23511419; DOI: 10.1038/nchem.1596

実験手法

X-RAY DIFFRACTION (3.08 Å)