2YAT
Crystal structure of estradiol derived metal chelate and estrogen receptor-ligand binding domain complex
Summary for 2YAT
| Entry DOI | 10.2210/pdb2yat/pdb |
| Related | 1A52 1AKF 1ERE 1ERR 1G50 1GWQ 1GWR 1HCP 1HCQ 1L2I 1PCG 1QKT 1QKU 1R5K 1SJ0 1UOM 1X7E 1X7R 1XP1 1XP6 1XP9 1XPC 1XQC 1YIM 1YIN 1ZKY 2AYR 2B1V 2BJ4 2FAI 2JF9 2JFA 3ERD 3ERT |
| Descriptor | ESTROGEN RECEPTOR, EUROPIUM ION, ESTRADIOL-PYRIDINIUM TETRAACETIC ACID, ... (5 entities in total) |
| Functional Keywords | transcription |
| Biological source | HOMO SAPIENS (HUMAN) |
| Cellular location | Isoform 1: Nucleus. Isoform 3: Nucleus: P03372 |
| Total number of polymer chains | 1 |
| Total formula weight | 29681.53 |
| Authors | Li, M.J.,Greenblatt, H.M.,Dym, O.,Albeck, S.,Degani, H.,Sussman, J.L. (deposition date: 2011-02-24, release date: 2011-06-01, Last modification date: 2023-12-20) |
| Primary citation | Li, M.J.,Greenblatt, H.M.,Dym, O.,Albeck, S.,Pais, A.,Gunanathan, C.,Milstein, D.,Degani, H.,Sussman, J.L. Structure of Estradiol Metal Chelate and Estrogen Receptor Complex: The Basis for Designing a New Class of Selective Estrogen Receptor Modulators. J.Med.Chem., 54:3575-, 2011 Cited by PubMed Abstract: Selective estrogen receptor modulators, such as 17β-estradiol derivatives bound to metal complexes, have been synthesized as targeted probes for the diagnosis and treatment of breast cancer. Here, we report the detailed 3D structure of estrogen receptor α ligand-binding domain (ERα-LBD) bound with a novel estradiol-derived metal complex, estradiol-pyridine tetra acetate europium(III), at 2.6 Å resolution. This structure provides important information pertinent to the design of novel functional ERα targeted probes for clinical applications. PubMed: 21473635DOI: 10.1021/JM200192Y PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.602 Å) |
Structure validation
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