Human estrogen receptor alpha ligand-binding domain in complex with OBCP-1M and a glucocorticoid receptor interacting protein 1 NR box II peptide

Summary for 2B1V

Related1ZKY 2B1V 2B1Z
DescriptorEstrogen receptor, Nuclear receptor coactivator 2, 4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-8-METHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL, ... (4 entities in total)
Functional Keywordsestrogen receptor, lbd, grip peptide, hormone-growth factor receptor complex, hormone/growth factor receptor
Biological sourceHomo sapiens (human)
Total number of polymer chains4
Total molecular weight62736.16
Rajan, S.S.,Hsieh, R.W.,Sharma, S.K.,Greene, G.L. (deposition date: 2005-09-16, release date: 2006-05-09, Last modification date: 2019-07-24)
Primary citation
Hsieh, R.W.,Rajan, S.S.,Sharma, S.K.,Guo, Y.,Desombre, E.R.,Mrksich, M.,Greene, G.L.
Identification of ligands with bicyclic scaffolds provides insights into mechanisms of estrogen receptor subtype selectivity.
J.Biol.Chem., 281:17909-17919, 2006
PubMed: 16648639 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M513684200
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.2386 0.2% 3.8% 4.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution