2B1V
Human estrogen receptor alpha ligand-binding domain in complex with OBCP-1M and a glucocorticoid receptor interacting protein 1 NR box II peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Estrogen receptor | polymer | 257 | 29527.9 | 2 | UniProt (P03372) Pfam (PF00104) | Homo sapiens (human) | ER, Estradiol receptor, ER-alpha |
| 2 | C, D (C, D) | Nuclear receptor coactivator 2 | polymer | 13 | 1579.9 | 2 | UniProt (Q15596) | NCoA-2, Transcriptional intermediary factor 2 | |
| 3 | E, F (A, B) | 4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-8-METHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL | non-polymer | 260.3 | 2 | Chemie (458) PubChem (16396095) PubChem (44300330) PubChem (49823328) PubChem (50897691) PubChem (2054901) PubChem (745250) PubChem (2828563) PubChem (6935782) PubChem (6852154) PubChem (11368962) PubChem (101334539) PubChem (6955054) PubChem (6955055) PubChem (156134778) PubChem (172966228) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 91 | Chemie (HOH) |
Sequence modifications
A, B: 298 - 554 (UniProt: P03372)
| PDB | External Database | Details |
|---|---|---|
| Cme 381 | Cys 381 | modified residue |
| Cme 417 | Cys 417 | modified residue |
| Cme 530 | Cys 530 | modified residue |
| Ser 537 | Tyr 537 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 62215.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 520.7 | |
| All* | Total formula weight | 62736.2 |
