2B1V
Human estrogen receptor alpha ligand-binding domain in complex with OBCP-1M and a glucocorticoid receptor interacting protein 1 NR box II peptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Estrogen receptor | polymer | 257 | 29527.9 | 2 | UniProt (P03372) Pfam (PF00104) | Homo sapiens (human) | ER, Estradiol receptor, ER-alpha |
| 2 | C, D (C, D) | Nuclear receptor coactivator 2 | polymer | 13 | 1579.9 | 2 | UniProt (Q15596) | NCoA-2, Transcriptional intermediary factor 2 | |
| 3 | E, F (A, B) | 4-[(1S,2S,5S)-5-(HYDROXYMETHYL)-8-METHYL-3-OXABICYCLO[3.3.1]NON-7-EN-2-YL]PHENOL | non-polymer | 260.3 | 2 | Chemie (458) | |||
| 4 | G, H (A, B) | water | water | 18.0 | 91 | Chemie (HOH) |
Sequence modifications
A, B: 298 - 554 (UniProt: P03372)
| PDB | External Database | Details |
|---|---|---|
| Cme 381 | Cys 381 | modified residue |
| Cme 417 | Cys 417 | modified residue |
| Cme 530 | Cys 530 | modified residue |
| Ser 537 | Tyr 537 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 62215.5 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 520.7 | |
| All* | Total formula weight | 62736.2 |
