2XRU

AURORA-A T288E COMPLEXED WITH PHA-828300

2XRU の概要

関連するPDBエントリー1MUO 2X6D 2J50 2W1D 1OL6 2XNE 2BMC 2C6E 2J4Z 1OL5 2X81 2XNG 2C6D 2WTW 2WQE 2W1C 2W1G 2WTV 1OL7 2W1E 2W1F 2X6E 1MQ4
分子名称SERINE/THREONINE-PROTEIN KINASE 6, 3-({[4-(4-METHYLPIPERAZIN-1-YL)PHENYL]CARBONYL}AMINO)-N-[(1R)-1-PHENYLPROPYL]-1H-THIENO[3,2-C]PYRAZOLE-5-CARBOXAMIDE (2 entities in total)
機能のキーワードnucleotide-binding, kinase, cell cycle, transferase
由来する生物種HOMO SAPIENS (HUMAN)
ポリマー鎖数1
分子量合計32899.71
構造登録者
主引用文献
Bindi, S.,Fancelli, D.,Alli, C.,Berta, D.,Bertrand, J.A.,Cameron, A.D.,Cappella, P.,Carpinelli, P.,Cervi, G.,Croci, V.,D'Anello, M.,Forte, B.,Laura Giorgini, M.,Marsiglio, A.,Moll, J.,Pesenti, E.,Pittala, V.,Pulici, M.,Riccardi-Sirtori, F.,Roletto, F.,Soncini, C.,Storici, P.,Varasi, M.,Volpi, D.,Zugnoni, P.,Vianello, P.
Thieno[3,2-C]Pyrazoles: A Novel Class of Aurora Inhibitors with Favorable Antitumor Activity.
Bioorg.Med.Chem., 18:7113-, 2010
PubMed: 20817473 (主引用文献が同じPDBエントリー)
DOI: 10.1016/J.BMC.2010.07.048
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (2.9 Å)
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構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.24945 6.8% 9.4% 5.9%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
検証レポート(詳細版)をダウンロード

他の静止画像(非対称単位)

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