2XRU
AURORA-A T288E COMPLEXED WITH PHA-828300
Summary for 2XRU
| Entry DOI | 10.2210/pdb2xru/pdb |
| Related | 1MQ4 1MUO 1OL5 1OL6 1OL7 2BMC 2C6D 2C6E 2J4Z 2J50 2W1C 2W1D 2W1E 2W1F 2W1G 2WQE 2WTV 2WTW 2X6D 2X6E 2X81 2XNE 2XNG |
| Descriptor | SERINE/THREONINE-PROTEIN KINASE 6, 3-({[4-(4-METHYLPIPERAZIN-1-YL)PHENYL]CARBONYL}AMINO)-N-[(1R)-1-PHENYLPROPYL]-1H-THIENO[3,2-C]PYRAZOLE-5-CARBOXAMIDE (2 entities in total) |
| Functional Keywords | nucleotide-binding, kinase, cell cycle, transferase |
| Biological source | HOMO SAPIENS (HUMAN) |
| Total number of polymer chains | 1 |
| Total formula weight | 32899.71 |
| Authors | Bindi, S.,Fancelli, D.,Alli, C.,Berta, D.,Bertrand, J.A.,Cameron, A.D.,Cappella, P.,Carpinelli, P.,Cervi, G.,Croci, W.,D'Anello, M.,Forte, B.,LauraGiorgini, M.,Marsiglio, A.,Moll, J.,Pesenti, E.,Pittala, V.,Pulici, M.,Riccardi-Sirtori, F.,Roletto, F.,Soncini, C.,Storici, P.,Varasi, M.,Volpi, D.,Zugnoni, P.,Vianello, P. (deposition date: 2010-09-22, release date: 2010-09-29, Last modification date: 2019-04-03) |
| Primary citation | Bindi, S.,Fancelli, D.,Alli, C.,Berta, D.,Bertrand, J.A.,Cameron, A.D.,Cappella, P.,Carpinelli, P.,Cervi, G.,Croci, V.,D'Anello, M.,Forte, B.,Laura Giorgini, M.,Marsiglio, A.,Moll, J.,Pesenti, E.,Pittala, V.,Pulici, M.,Riccardi-Sirtori, F.,Roletto, F.,Soncini, C.,Storici, P.,Varasi, M.,Volpi, D.,Zugnoni, P.,Vianello, P. Thieno[3,2-C]Pyrazoles: A Novel Class of Aurora Inhibitors with Favorable Antitumor Activity. Bioorg.Med.Chem., 18:7113-, 2010 Cited by PubMed: 20817473DOI: 10.1016/J.BMC.2010.07.048 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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