2XRU
AURORA-A T288E COMPLEXED WITH PHA-828300
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | SERINE/THREONINE-PROTEIN KINASE 6 | polymer | 280 | 32397.1 | 1 | UniProt (O14965) Pfam (PF00069) | HOMO SAPIENS (HUMAN) | AURORA KINASE A, SERINE/THREONINE KINASE 15, AURORA/IPL1-RELATED KINASE 1, BREAST TUMOR-AMPLIFIED KINASE, AURORA-A, AURORA-RELATED KINASE 1, HARK1 |
| 2 | B (A) | 3-({[4-(4-METHYLPIPERAZIN-1-YL)PHENYL]CARBONYL}AMINO)-N-[(1R)-1-PHENYLPROPYL]-1H-THIENO[3,2-C]PYRAZOLE-5-CARBOXAMIDE | non-polymer | 502.6 | 1 | Chemie (400) |
Sequence modifications
A: 126 - 403 (UniProt: O14965)
| PDB | External Database | Details |
|---|---|---|
| Gly 124 | - | expression tag |
| Pro 125 | - | expression tag |
| Glu 288 | Thr 288 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 32397.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 502.6 | |
| All* | Total formula weight | 32899.7 |
