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2X81

STRUCTURE OF AURORA A IN COMPLEX WITH MLN8054

Summary for 2X81
Entry DOI10.2210/pdb2x81/pdb
Related1MQ4 1MUO 1OL5 1OL6 1OL7 2BMC 2C6D 2C6E 2J4Z 2J50 2W1C 2W1D 2W1E 2W1F 2W1G 2WQE 2WTV 2WTW 2X6D
DescriptorSERINE/THREONINE-PROTEIN KINASE 6, 4-{[9-CHLORO-7-(2,6-DIFLUOROPHENYL)-5H-PYRIMIDO[5,4-D][2]BENZAZEPIN-2-YL]AMINO}BENZOIC ACID (2 entities in total)
Functional Keywordstransferase, drug-resistance, cell cycle, cytoskeleton
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationCytoplasm, cytoskeleton, microtubule organizing center, centrosome : O14965
Total number of polymer chains1
Total formula weight31917.01
Authors
Savory, W.,Mueller, I.,Mason, C.S.,Lamers, M.,Williams, D.H.,Eyers, P.A. (deposition date: 2010-03-05, release date: 2010-05-05, Last modification date: 2023-12-20)
Primary citationSloane, D.,Trikic, M.,Chu, M.L.,Lamers, M.,Mason, C.S.,Mueller, I.,Savory, W.,Williams, D.H.,Eyers, P.A.
Drug-Resistant Aurora a Mutants for Cellular Target Validation of the Small Molecule Kinase Inhibitors Mln8054 and Mln8237.
Acs Chem.Biol., 5:563-, 2010
Cited by
PubMed: 20426425
DOI: 10.1021/CB100053Q
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.91 Å)
Structure validation

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