2X81

STRUCTURE OF AURORA A IN COMPLEX WITH MLN8054

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	SERINE/THREONINE-PROTEIN KINASE 6	polymer	272	31440.2	1	UniProt (O14965) Pfam (PF00069) In PDB	HOMO SAPIENS (HUMAN)	AURORA A, AURORA KINASE A, SERINE/THREONINE-PROTEIN KINASE AURORA-A, SERINE/THREONINE-PROTEIN KINASE 15, AURORA/IPL1-RELATED KINASE 1, AURORA-RELATED KINASE 1, ARK-1, HARK1, BREAST TUMOR-AMPLIFIED KINASE
2	A	4-{[9-CHLORO-7-(2,6-DIFLUOROPHENYL)-5H-PYRIMIDO[5,4-D][2]BENZAZEPIN-2-YL]AMINO}BENZOIC ACID	non-polymer		476.9	1	Chemie (ZZL)

Sequence modifications

A: 120 - 125 (PDB: 2X81)
A: 126 - 391 (UniProt: O14965)

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	31440.2
Non-Polymers*	Number of molecules	1
	Total formula weight	476.9
All*	Total formula weight	31917.0

*Water molecules are not included.