2WTW

Aurora-A Inhibitor Structure (2nd crystal form)

Summary for 2WTW

Related1MUO 2J50 2W1D 1OL6 2BMC 2C6E 2J4Z 1OL5 2C6D 2WQE 2W1C 2W1G 2WTV 1OL7 2W1E 2W1F 1MQ4
DescriptorSERINE/THREONINE-PROTEIN KINASE 6 AURORA/IPL1-RELATED KINASE 1, BREAST TUMOR-AMPLIFIED KINASE, AURORA-A, AURORA-RELATED KINASE 1, HARK1, 4-{[9-CHLORO-7-(2,6-DIFLUOROPHENYL)-5H-PYRIMIDO[5,4-D][2]BENZAZEPIN-2-YL]AMINO}BENZOIC ACID (2 entities in total)
Functional Keywordskinase, cell cycle, transferase, phosphoprotein, protein kinase
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationCytoplasm, cytoskeleton, centrosome O14965
Total number of polymer chains1
Total molecular weight33469.68
Authors
Kosmopoulou, M.,Bayliss, R. (deposition date: 2009-09-24, release date: 2010-01-26, Last modification date: 2011-07-13)
Primary citation
Dodson, C.A.,Kosmopoulou, M.,Richards, M.W.,Atrash, B.,Bavetsias, V.,Blagg, J.,Bayliss, R.
Crystal Structure of an Aurora-A Mutant that Mimics Aurora-B Bound to Mln8054: Insights Into Selectivity and Drug Design.
Biochem.J., 427:19-, 2010
PubMed: 20067443 (PDB entries with the same primary citation)
DOI: 10.1042/BJ20091530
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.302 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.287241.6%6.0%0.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution