2BMC

Aurora-2 T287D T288D complexed with PHA-680632

Summary for 2BMC

Related1MQ4 1MUO 1OL5 1OL6 1OL7
DescriptorSERINE THREONINE-PROTEIN KINASE 6, (3E)-N-(2,6-DIETHYLPHENYL)-3-{[4-(4-METHYLPIPERAZIN-1-YL)BENZOYL]IMINO}PYRROLO[3,4-C]PYRAZOLE-5(3H)-CARBOXAMIDE (3 entities in total)
Functional Keywordscell cycle, transferase, serine/threonine-protein kinase, atp-binding, phosphorylation
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains6
Total molecular weight214816.53
Authors
Primary citation
Fancelli, D.,Berta, D.,Bindi, S.,Cameron, A.,Cappella, P.,Carpinelli, P.,Catana, C.,Forte, B.,Giordano, P.,Giorgini, M.L.,Mantegani, S.,Marsiglio, A.,Meroni, M.,Moll, J.,Pittala, V.,Roletto, F.,Severino, D.,Soncini, C.,Storici, P.,Tonani, R.,Varasi, M.,Vulpetti, A.,Vianello, P.
Potent and Selective Aurora Inhibitors Identified by the Expansion of a Novel Scaffold for Protein Kinase Inhibition.
J.Med.Chem., 48:3080-, 2005
PubMed: 15828847 (PDB entries with the same primary citation)
DOI: 10.1021/JM049076M
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.6 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers14 0.7% 3.2%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution