2BMC

Aurora-2 T287D T288D complexed with PHA-680632

Summary for 2BMC

• Entry DOI: 10.2210/pdb2bmc/pdb
• Related: 1MQ4 1MUO 1OL5 1OL6 1OL7
• Descriptor: SERINE THREONINE-PROTEIN KINASE 6, (3E)-N-(2,6-DIETHYLPHENYL)-3-{[4-(4-METHYLPIPERAZIN-1-YL)BENZOYL]IMINO}PYRROLO[3,4-C]PYRAZOLE-5(3H)-CARBOXAMIDE (3 entities in total)
• Functional Keywords: cell cycle, transferase, serine/threonine-protein kinase, atp-binding, phosphorylation
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 6
• Total formula weight: 214816.53

Authors

Cameron, A.D.,Izzo, G.,Sagliano, A.,Rusconi, L.,Storici, P.,Fancelli, D.,Berta, D.,Bindi, S.,Catana, C.,Forte, B.,Giordano, P.,Mantegani, S.,Meroni, M.,Moll, J.,Pittala, V.,Severino, D.,Tonani, R.,Varasi, M.,Vulpetti, A.,Vianello, P. (deposition date: 2005-03-11, release date: 2005-03-17, Last modification date: 2019-08-21)

• Primary citation: Fancelli, D.,Berta, D.,Bindi, S.,Cameron, A.,Cappella, P.,Carpinelli, P.,Catana, C.,Forte, B.,Giordano, P.,Giorgini, M.L.,Mantegani, S.,Marsiglio, A.,Meroni, M.,Moll, J.,Pittala, V.,Roletto, F.,Severino, D.,Soncini, C.,Storici, P.,Tonani, R.,Varasi, M.,Vulpetti, A.,Vianello, P.; Potent and Selective Aurora Inhibitors Identified by the Expansion of a Novel Scaffold for Protein Kinase Inhibition.; J.Med.Chem., 48:3080-, 2005; PubMed: 15828847; DOI: 10.1021/JM049076M

Experimental method

X-RAY DIFFRACTION (2.6 Å)