2WTW

Aurora-A Inhibitor Structure (2nd crystal form)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	SERINE/THREONINE-PROTEIN KINASE 6 AURORA/IPL1-RELATED KINASE 1, BREAST TUMOR-AMPLIFIED KINASE, AURORA-A, AURORA-RELATED KINASE 1, HARK1	polymer	285	32992.8	1	UniProt (O14965) Pfam (PF00069) In PDB	HOMO SAPIENS (HUMAN)
2	A	4-{[9-CHLORO-7-(2,6-DIFLUOROPHENYL)-5H-PYRIMIDO[5,4-D][2]BENZAZEPIN-2-YL]AMINO}BENZOIC ACID	non-polymer		476.9	1	Chemie (ZZL)

Sequence modifications

A: 119 - 121 (PDB: 2WTW)
A: 122 - 403 (UniProt: O14965)

PDB	External Database	Details
Arg 215	Leu 215	engineered mutation
Glu 217	Thr 217	engineered mutation
Lys 220	Arg 220	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	32992.8
Non-Polymers*	Number of molecules	1
	Total formula weight	476.9
All*	Total formula weight	33469.7

*Water molecules are not included.