2VUM
Alpha-amanitin inhibited complete RNA polymerase II elongation complex
Summary for 2VUM
Entry DOI | 10.2210/pdb2vum/pdb |
Related | 1A1D 1DZF 1I3Q 1I50 1I6H 1K83 1NIK 1NT9 1PQV 1R5U 1R9S 1R9T 1SFO 1TWA 1TWC 1TWF 1TWG 1TWH 1WCM 1Y14 1Y1V 1Y1W 1Y1Y 1Y77 2B63 2B8K 2JA5 2JA6 2JA7 2JA8 |
Descriptor | DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1, DNA-DIRECTED RNA POLYMERASES I, II, AND III SUBUNIT RPABC5, DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB11, ... (18 entities in total) |
Functional Keywords | transferase, dna-directed rna polymerase, alpha-amanitin, ubl conjugation, nuclear protein, rna polymerase ii, elongation complex, mrna processing, phosphorylation, enzyme inhibition, dna damage, dna repair, zinc-finger, dna-binding, transferase/dna/rna, transcription bubble, zinc, nucleus, cytoplasm, inhibitor, magnesium, transcription inhibition, translocation intermediate, transcription, metal-binding, phosphoprotein, intermediate, fungal toxin, polymorphism, nucleotidyltransferase, transcription mechanism |
Biological source | SACCHAROMYCES CEREVISIAE (BAKERS' YEAST) More |
Total number of polymer chains | 16 |
Total formula weight | 531503.86 |
Authors | Brueckner, F.,Cramer, P. (deposition date: 2008-05-27, release date: 2008-06-17, Last modification date: 2023-12-13) |
Primary citation | Brueckner, F.,Cramer, P. Structural Basis of Transcription Inhibition by Alpha-Amanitin and Implications for RNA Polymerase II Translocation. Nat.Struct.Mol.Biol., 15:811-, 2008 Cited by PubMed: 18552824DOI: 10.1038/NSMB.1458 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.4 Å) |
Structure validation
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