2VUM

Alpha-amanitin inhibited complete RNA polymerase II elongation complex

Summary for 2VUM

Related1TWC 1I6H 1Y1V 1Y77 1Y1Y 1WCM 1R9S 1TWG 1SFO 1I50 1TWA 1R5U 1NIK 1TWH 1R9T 2JA7 2JA6 1A1D 1K83 1DZF 1Y14 1Y1W 1NT9 2B63 1TWF 1I3Q 1PQV 2B8K 2JA8 2JA5
DescriptorDNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB1, DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB2, DNA-DIRECTED RNA POLYMERASE II SUBUNIT RPB3, ... (18 entities in total)
Functional Keywordstransferase, dna-directed rna polymerase, alpha-amanitin, ubl conjugation, nuclear protein, rna polymerase ii, elongation complex, mrna processing, phosphorylation, enzyme inhibition, dna damage, dna repair, zinc-finger, dna-binding, transferase/dna/rna, transcription bubble, zinc, nucleus, cytoplasm, inhibitor, magnesium, transcription inhibition, translocation intermediate, transcription, metal-binding, phosphoprotein, intermediate, fungal toxin, polymorphism, nucleotidyltransferase, transcription mechanism
Biological sourceSACCHAROMYCES CEREVISIAE (BAKERS' YEAST)
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Total number of polymer chains16
Total molecular weight531503.86
Authors
Brueckner, F.,Cramer, P. (deposition date: 2008-05-27, release date: 2008-06-17, Last modification date: 2018-06-27)
Primary citation
Brueckner, F.,Cramer, P.
Structural Basis of Transcription Inhibition by Alpha-Amanitin and Implications for RNA Polymerase II Translocation.
Nat.Struct.Mol.Biol., 15:811-, 2008
PubMed: 18552824 (PDB entries with the same primary citation)
DOI: 10.1038/NSMB.1458
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3.4 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliersRNA backbone0.2875510.9%9.1%1.1%0.64MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report