2VUK

Structure of the p53 core domain mutant Y220C bound to the stabilizing small-molecule drug PhiKan083

2VUK の概要

• エントリーDOI: 10.2210/pdb2vuk/pdb
• 関連するPDBエントリー: 1A1U 1AIE 1C26 1DT7 1GZH 1H26 1HS5 1JSP 1KZY 1MA3 1OLG 1OLH 1PES 1PET 1SAE 1SAF 1SAG 1SAH 1SAI 1SAJ 1SAK 1SAL 1TSR 1TUP 1UOL 1XQH 1YCQ 1YCR 1YCS 2AC0 2ADY 2AHI 2ATA 2B3G 2BIM 2BIN 2BIO 2BIP 2BIQ 2FEJ 2GS0 2H1L 2J0Z 2J10 2J11 2J1W 2J1X 2J1Y 2J1Z 2J20 2J21 3SAK
• 分子名称: CELLULAR TUMOR ANTIGEN P53, ZINC ION, 1-(9-ethyl-9H-carbazol-3-yl)-N-methylmethanamine, ... (4 entities in total)
• 機能のキーワード: metal binding, phosphoprotein, ubl conjugation, activator, cell cycle, acetylation, methylation, zinc, cancer, nucleus, apoptosis, cytoplasm, tumor suppressor, virtual screening, second-site suppressor mutation, covalent protein-rna linkage, small-molecule drug, alternative splicing, p53 dna- binding domain, transcription regulation, nuclear protein, surface crevice, disease mutation, protein stabilization, host-virus interaction, li-fraumeni syndrome, endoplasmic reticulum, metal-binding, anti-oncogene, transcription, superstable mutant, dna-binding protein, dna binding, dna-binding, polymorphism, glycoprotein
• 由来する生物種: HOMO SAPIENS (HUMAN)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 49430.77

構造登録者

Joerger, A.C.,Boeckler, F.M.,Fersht, A.R. (登録日: 2008-05-26, 公開日: 2008-07-22, 最終更新日: 2023-12-13)

• 主引用文献: Boeckler, F.M.,Joerger, A.C.,Jaggi, G.,Rutherford, T.J.,Veprintsev, D.B.,Fersht, A.R.; Targeted Rescue of a Destabilized Mutant of P53 by an in Silico Screened Drug.; Proc.Natl.Acad.Sci.USA, 105:10360-, 2008; PubMed: 18650397; DOI: 10.1073/PNAS.0805326105

実験手法

X-RAY DIFFRACTION (1.5 Å)