2CHM

Crystal structure of N2 substituted pyrazolo pyrimidinones - a flipped binding mode in PDE5

Summary for 2CHM

Entry DOI	10.2210/pdb2chm/pdb
Related	1F0J 1JP1 1JP2 1RKP 1RO6 1RO9 1ROR 1T9R 1T9S 1TB5 1TBF 1UDT 1UDU 1UHO 1XLX 1XLZ 1XM4 1XM6 1XMU 1XMY 1XN0 1XOS 1XOT 1XOZ 1XP0 1Y2H 1Y2J
Descriptor	CGMP-SPECIFIC 3', 5'-CYCLIC PHOSPHODIESTERASE, CAMP-SPECIFIC 3', 5'-CYCLIC PHOSPHODIESTERASE 4B, ZINC ION, MAGNESIUM ION, ... (6 entities in total)
Functional Keywords	phosphodiesterase 5, inhibitor, chimera, allosteric enzyme, alternative splicing, cgmp, cgmp-binding, hydrolase, magnesium, metal-binding, nucleotide-binding, phosphorylation, zinc, camp
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	1
Total formula weight	38332.68
Authors	Allerton, C.M.N.,Barber, C.G.,Beaumont, K.C.,Brown, D.G.,Cole, S.M.,Ellis, D.,Lane, C.A.L.,Maw, G.N.,Mount, N.M.,Rawson, D.J.,Robinson, C.M.,Street, S.D.A.,Summerhill, N.W. (deposition date: 2006-03-15, release date: 2006-06-08, Last modification date: 2019-03-27)
Primary citation	Allerton, C.M.N.,Barber, C.G.,Beaumont, K.C.,Brown, D.G.,Cole, S.M.,Ellis, D.,Lane, C.A.L.,Maw, G.N.,Mount, N.M.,Rawson, D.J.,Robinson, C.M.,Street, S.D.A.,Summerhill, N.W. A Novel Series of Potent and Selective Pde5 Inhibitors with Potential for High and Dose-Independent Oral Bioavailability J.Med.Chem., 49:3581-, 2006 Cited by PubMed: 16759100 DOI: 10.1021/JM060113E PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation