1XOZ
Catalytic Domain Of Human Phosphodiesterase 5A In Complex With Tadalafil
Summary for 1XOZ
Entry DOI | 10.2210/pdb1xoz/pdb |
Related | 1XLX 1XLZ 1XM4 1XM6 1XMU 1XMY 1XN0 1XOM 1XON 1XOQ 1XOR 1XOS 1XOT 1XP0 |
Descriptor | cGMP-specific 3',5'-cyclic phosphodiesterase, ZINC ION, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | phosphodiesterase, pde, pde5a, tadalafil, cialis, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 42307.05 |
Authors | Card, G.L.,England, B.P.,Suzuki, Y.,Fong, D.,Powell, B.,Lee, B.,Luu, C.,Tabrizizad, M.,Gillette, S.,Ibrahim, P.N.,Artis, D.R.,Bollag, G.,Milburn, M.V.,Kim, S.-H.,Schlessinger, J.,Zhang, K.Y.J. (deposition date: 2004-10-07, release date: 2004-12-14, Last modification date: 2024-02-14) |
Primary citation | Card, G.L.,England, B.P.,Suzuki, Y.,Fong, D.,Powell, B.,Lee, B.,Luu, C.,Tabrizizad, M.,Gillette, S.,Ibrahim, P.N.,Artis, D.R.,Bollag, G.,Milburn, M.V.,Kim, S.-H.,Schlessinger, J.,Zhang, K.Y.J. Structural Basis for the Activity of Drugs that Inhibit Phosphodiesterases. STRUCTURE, 12:2233-2247, 2004 Cited by PubMed: 15576036DOI: 10.1016/j.str.2004.10.004 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.37 Å) |
Structure validation
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