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1TBF

Catalytic Domain Of Human Phosphodiesterase 5A in Complex with Sildenafil

Summary for 1TBF
Entry DOI10.2210/pdb1tbf/pdb
Related1T9R 1T9S 1TAZ 1TB5 1TB7 1TBB
DescriptorcGMP-specific 3',5'-cyclic phosphodiesterase, ZINC ION, MAGNESIUM ION, ... (6 entities in total)
Functional Keywordspde5a, hydrolase
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total formula weight40568.17
Authors
Zhang, K.Y.J.,Card, G.L.,Suzuki, Y.,Artis, D.R.,Fong, D.,Gillette, S.,Hsieh, D.,Neiman, J.,West, B.L.,Zhang, C.,Milburn, M.V.,Kim, S.-H.,Schlessinger, J.,Bollag, G. (deposition date: 2004-05-20, release date: 2004-08-03, Last modification date: 2023-08-23)
Primary citationZhang, K.Y.J.,Card, G.L.,Suzuki, Y.,Artis, D.R.,Fong, D.,Gillette, S.,Hsieh, D.,Neiman, J.,West, B.L.,Zhang, C.,Milburn, M.V.,Kim, S.-H.,Schlessinger, J.,Bollag, G.
A Glutamine Switch Mechanism for Nucleotide Selectivity by Phosphodiesterases
Mol.Cell, 15:279-286, 2004
Cited by
PubMed: 15260978
DOI: 10.1016/j.molcel.2004.07.005
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.3 Å)
Structure validation

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