1TBF
Catalytic Domain Of Human Phosphodiesterase 5A in Complex with Sildenafil
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | cGMP-specific 3',5'-cyclic phosphodiesterase | polymer | 347 | 39911.8 | 1 | UniProt (O76074) Pfam (PF00233) | Homo sapiens (human) | CGB-PDE, cGMP-binding cGMP-specific phosphodiesterase |
| 2 | B (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 3 | C (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 4 | D (A) | 5-{2-ETHOXY-5-[(4-METHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-1-METHYL-3-PROPYL-1H,6H,7H-PYRAZOLO[4,3-D]PYRIMIDIN-7-ONE | non-polymer | 474.6 | 1 | Chemie (VIA) | |||
| 5 | E (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 6 | F (A) | water | water | 18.0 | 323 | Chemie (HOH) |
Sequence modifications
A: 534 - 858 (UniProt: O76074)
| PDB | External Database | Details |
|---|---|---|
| Met 513 | - | expression tag |
| Gly 514 | - | expression tag |
| Ser 515 | - | expression tag |
| Ser 516 | - | expression tag |
| His 517 | - | expression tag |
| His 518 | - | expression tag |
| His 519 | - | expression tag |
| His 520 | - | expression tag |
| His 521 | - | expression tag |
| His 522 | - | expression tag |
| Ser 523 | - | expression tag |
| Ser 524 | - | expression tag |
| Gly 525 | - | expression tag |
| Leu 526 | - | expression tag |
| Val 527 | - | expression tag |
| Pro 528 | - | expression tag |
| Arg 529 | - | expression tag |
| Gly 530 | - | expression tag |
| Ser 531 | - | expression tag |
| His 532 | - | expression tag |
| Met 533 | - | expression tag |
| Pro 658 | Arg 658 | engineered mutation |
| Ser 661 | Asn 661 | engineered mutation |
| Gln 663 | Ser 663 | engineered mutation |
| Phe 664 | Tyr 664 | engineered mutation |
| Leu 665 | Ile 665 | engineered mutation |
| Ile 666 | Gln 666 | engineered mutation |
| Asn 667 | Arg 667 | engineered mutation |
| Thr 668 | Ser 668 | engineered mutation |
| Asn 669 | Glu 669 | engineered mutation |
| Ser 670 | His 670 | engineered mutation |
| Glu 671 | Pro 671 | engineered mutation |
| Leu 674 | Gln 674 | engineered mutation |
| Met 675 | Leu 675 | engineered mutation |
| Asn 676 | Cys 677 | engineered mutation |
| Asp 677 | - | engineered mutation |
| Glu 678 | His 678 | engineered mutation |
| Val 680 | Ile 680 | engineered mutation |
| Leu 681 | Met 681 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 39911.8 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 656.4 | |
| All* | Total formula weight | 40568.2 |
