1TBF
Catalytic Domain Of Human Phosphodiesterase 5A in Complex with Sildenafil
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | cGMP-specific 3',5'-cyclic phosphodiesterase | polymer | 347 | 39911.8 | 1 | UniProt (O76074) Pfam (PF00233) In PDB | Homo sapiens (human) | CGB-PDE, cGMP-binding cGMP-specific phosphodiesterase |
2 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
3 | A | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
4 | A | 5-{2-ETHOXY-5-[(4-METHYLPIPERAZIN-1-YL)SULFONYL]PHENYL}-1-METHYL-3-PROPYL-1H,6H,7H-PYRAZOLO[4,3-D]PYRIMIDIN-7-ONE | non-polymer | 474.6 | 1 | Chemie (VIA) | |||
5 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
6 | water | water | 18.0 | 323 | Chemie (HOH) |
Sequence modifications
A: 534 - 858 (UniProt: O76074)
PDB | External Database | Details |
---|---|---|
Met 513 | - | expression tag |
Gly 514 | - | expression tag |
Ser 515 | - | expression tag |
Ser 516 | - | expression tag |
His 517 | - | expression tag |
His 518 | - | expression tag |
His 519 | - | expression tag |
His 520 | - | expression tag |
His 521 | - | expression tag |
His 522 | - | expression tag |
Ser 523 | - | expression tag |
Ser 524 | - | expression tag |
Gly 525 | - | expression tag |
Leu 526 | - | expression tag |
Val 527 | - | expression tag |
Pro 528 | - | expression tag |
Arg 529 | - | expression tag |
Gly 530 | - | expression tag |
Ser 531 | - | expression tag |
His 532 | - | expression tag |
Met 533 | - | expression tag |
Pro 658 | Arg 658 | engineered mutation |
Ser 661 | Asn 661 | engineered mutation |
Gln 663 | Ser 663 | engineered mutation |
Phe 664 | Tyr 664 | engineered mutation |
Leu 665 | Ile 665 | engineered mutation |
Ile 666 | Gln 666 | engineered mutation |
Asn 667 | Arg 667 | engineered mutation |
Thr 668 | Ser 668 | engineered mutation |
Asn 669 | Glu 669 | engineered mutation |
Ser 670 | His 670 | engineered mutation |
Glu 671 | Pro 671 | engineered mutation |
Leu 674 | Gln 674 | engineered mutation |
Met 675 | Leu 675 | engineered mutation |
Asn 676 | Cys 677 | engineered mutation |
Asp 677 | - | engineered mutation |
Glu 678 | His 678 | engineered mutation |
Val 680 | Ile 680 | engineered mutation |
Leu 681 | Met 681 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 39911.8 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 656.4 | |
All* | Total formula weight | 40568.2 |