1TBF
Catalytic Domain Of Human Phosphodiesterase 5A in Complex with Sildenafil
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE ZN A 1 |
| Chain | Residue |
| A | MG2 |
| A | HIS617 |
| A | HIS653 |
| A | ASP654 |
| A | ASP764 |
| A | HOH1175 |
| A | HOH1180 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | BINDING SITE FOR RESIDUE MG A 2 |
| Chain | Residue |
| A | HOH1175 |
| A | HOH1176 |
| A | HOH1177 |
| A | HOH1178 |
| A | HOH1179 |
| A | ZN1 |
| A | ASP654 |
| site_id | AC3 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE VIA A 501 |
| Chain | Residue |
| A | TYR612 |
| A | ALA779 |
| A | PHE786 |
| A | LEU804 |
| A | GLN817 |
| A | PHE820 |
| A | HOH890 |
| A | HOH951 |
| A | HOH1027 |
| A | HOH1181 |
| site_id | AC4 |
| Number of Residues | 8 |
| Details | BINDING SITE FOR RESIDUE GOL A 502 |
| Chain | Residue |
| A | PHE664 |
| A | ASN667 |
| A | GLN789 |
| A | GLU793 |
| A | HIS834 |
| A | HOH873 |
| A | HOH884 |
| A | HOH903 |
Functional Information from PROSITE/UniProt
| site_id | PS00126 |
| Number of Residues | 12 |
| Details | PDEASE_I_1 3'5'-cyclic nucleotide phosphodiesterase domain signature. HDLdHpGvsNqF |
| Chain | Residue | Details |
| A | HIS653-PHE664 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"UniProtKB","id":"O76083","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12955149","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15260978","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1T9R","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1T9S","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1TBF","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"12955149","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
