1RO6

Crystal structure of PDE4B2B complexed with Rolipram (R & S)

Summary for 1RO6

• Entry DOI: 10.2210/pdb1ro6/pdb
• Related: 1RO9 1ROR
• Descriptor: cAMP-specific 3',5'-cyclic phosphodiesterase 4B, ZINC ION, MANGANESE (II) ION, ... (6 entities in total)
• Functional Keywords: pde, rolipram, crystal, hydrolase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 87770.01

Authors

Xu, R.X.,Rocque, W.J.,Lambert, M.H.,Vanderwall, D.E.,Nolte, R.T. (deposition date: 2003-12-01, release date: 2004-12-07, Last modification date: 2024-04-03)

• Primary citation: Xu, R.X.,Rocque, W.J.,Lambert, M.H.,Vanderwall, D.E.,Luther, M.A.,Nolte, R.T.; Crystal structures of the catalytic domain of phosphodiesterase 4B complexed with AMP, 8-Br-AMP, and rolipram.; J.Mol.Biol., 337:355-365, 2004; PubMed: 15003452; DOI: 10.1016/j.jmb.2004.01.040

Experimental method

X-RAY DIFFRACTION (2 Å)