1UDU
Crystal structure of Human Phosphodiesterase 5 complexed with tadalafil(Cialis)
Summary for 1UDU
Entry DOI | 10.2210/pdb1udu/pdb |
Related | 1UDT |
Descriptor | cGMP-specific 3',5'-cyclic phosphodiesterase, ZINC ION, MAGNESIUM ION, ... (4 entities in total) |
Functional Keywords | cgmp-specific phosphodiesterase 5, tadalafil, selective inhibitor, hydrolase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 76018.85 |
Authors | Sung, B.-J.,Lee, J.I.,Heo, Y.-S.,Kim, J.H.,Moon, J.,Yoon, J.M.,Hyun, Y.-L.,Kim, E.,Eum, S.J.,Lee, T.G.,Cho, J.M.,Park, S.-Y.,Lee, J.-O.,Jeon, Y.H.,Hwang, K.Y.,Ro, S. (deposition date: 2003-05-06, release date: 2004-05-11, Last modification date: 2023-12-27) |
Primary citation | Sung, B.-J.,Hwang, K.Y.,Jeon, Y.H.,Lee, J.I.,Heo, Y.-S.,Kim, J.H.,Moon, J.,Yoon, J.M.,Hyun, Y.-L.,Kim, E.,Eum, S.J.,Park, S.-Y.,Lee, J.-O.,Lee, T.G.,Ro, S.,Cho, J.M. Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules Nature, 425:98-102, 2003 Cited by PubMed: 12955149DOI: 10.1038/nature01914 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.83 Å) |
Structure validation
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