1UDU

Crystal structure of Human Phosphodiesterase 5 complexed with tadalafil(Cialis)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	cGMP-specific 3',5'-cyclic phosphodiesterase	polymer	324	37530.3	2	UniProt (O76074) Pfam (PF00233) In PDB	Homo sapiens (human)	Phosphodiesterase 5
2	A, B	ZINC ION	non-polymer		65.4	2	Chemie (ZN)
3	A, B	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
4	A, B	6-BENZO[1,3]DIOXOL-5-YL-2-METHYL-2,3,6,7,12,12A-HEXAHYDRO-PYRAZINO[1',2':1,6]PYRIDO[3,4-B]INDOLE-1,4-DIONE	non-polymer		389.4	2	Chemie (CIA)

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	75060.6
Non-Polymers*	Number of molecules	6
	Total formula weight	958.2
All*	Total formula weight	76018.8

*Water molecules are not included.