1UDT

Crystal structure of Human Phosphodiesterase 5 complexed with Sildenafil(Viagra)

Summary for 1UDT

Entry DOI	10.2210/pdb1udt/pdb
Related	1UDU
Descriptor	cGMP-specific 3',5'-cyclic phosphodiesterase, ZINC ION, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	cgmp-specific phosphodiesterase 5, sildenafil, selective inhibitor, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	38094.60
Authors	Sung, B.-J.,Lee, J.I.,Heo, Y.-S.,Kim, J.H.,Moon, J.,Yoon, J.M.,Hyun, Y.-L.,Kim, E.,Eum, S.J.,Lee, T.G.,Cho, J.M.,Park, S.-Y.,Lee, J.-O.,Jeon, Y.H.,Hwang, K.Y.,Ro, S. (deposition date: 2003-05-06, release date: 2004-05-11, Last modification date: 2023-12-27)
Primary citation	Sung, B.-J.,Hwang, K.Y.,Jeon, Y.H.,Lee, J.I.,Heo, Y.-S.,Kim, J.H.,Moon, J.,Yoon, J.M.,Hyun, Y.-L.,Kim, E.,Eum, S.J.,Park, S.-Y.,Lee, J.-O.,Lee, T.G.,Ro, S.,Cho, J.M. Structure of the catalytic domain of human phosphodiesterase 5 with bound drug molecules Nature, 425:98-102, 2003 Cited by PubMed: 12955149 DOI: 10.1038/nature01914 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation