2UZV
PKA structures of indazole-pyridine series of AKT inhibitors
Summary for 2UZV
Entry DOI | 10.2210/pdb2uzv/pdb |
Related | 1KMU 1KMW 1Q24 1Q61 1Q62 1Q8T 1Q8U 1Q8W 1SMH 1STC 1SVE 1SVG 1SVH 1SZM 1VEB 1XH4 1XH5 1XH6 1XH7 1XH8 1XH9 1XHA 1YDR 1YDS 1YDT 2C1A 2C1B 2F7E 2GFC 2GNF 2GNG 2GNH 2GNI 2GNJ 2GNL 2JDS 2JDT 2JDV 2UVX 2UVY 2UVZ 2UW0 2UW3 2UW4 2UW5 2UW6 2UW7 2UW8 2UZT 2UZU 2UZW |
Descriptor | CAMP-DEPENDENT PROTEIN KINASE INHIBITOR ALPHA,, CAMP-DEPENDENT PROTEIN KINASE, ALPHA-CATALYTIC SUBUNIT, (2S)-1-[3-(CYCLOHEXYLMETHOXY)PHENYL]-3-{[5-(3-METHYL-1H-INDAZOL-5-YL)PYRIDIN-3-YL]OXY}PROPAN-2-AMINE (3 entities in total) |
Functional Keywords | camp, kinase, myristate, transferase, lipoprotein, serine/threonine-protein kinase, phosphorylation, protein kinase a, nucleotide-binding, atp-binding, akt inhibitors, nuclear protein |
Biological source | BOS TAURUS (BOVINE) More |
Cellular location | Cytoplasm: P00517 |
Total number of polymer chains | 2 |
Total formula weight | 41913.08 |
Authors | Zhu, G.D.,Gandhi, V.B.,Gong, J.,Thomas, S.,Woods, K.W.,Song, X.,Li, T.,Diebold, R.B.,Luo, Y.,Liu, X.,Guan, R.,Klinghofer, V.,Johnson, E.F.,Bouska, J.,Olson, A.,Marsh, K.C.,Stoll, V.S.,Mamo, M.,Polakowski, J.,Campbell, T.J.,Penning, T.D.,Li, Q.,Rosenberg, S.H.,Giranda, V.L. (deposition date: 2007-05-01, release date: 2007-06-05, Last modification date: 2024-05-08) |
Primary citation | Zhu, G.D.,Gandhi, V.B.,Gong, J.,Thomas, S.,Woods, K.W.,Song, X.,Li, T.,Diebold, R.B.,Luo, Y.,Liu, X.,Guan, R.,Klinghofer, V.,Johnson, E.F.,Bouska, J.,Olson, A.,Marsh, K.C.,Stoll, V.S.,Mamo, M.,Polakowski, J.,Campbell, T.J.,Martin, R.L.,Gintant, G.A.,Penning, T.D.,Li, Q.,Rosenberg, S.H.,Giranda, V.L. Syntheses of Potent, Selective, and Orally Bioavailable Indazole-Pyridine Series of Protein Kinase B/Akt Inhibitors with Reduced Hypotension. J.Med.Chem., 50:2990-, 2007 Cited by PubMed: 17523610DOI: 10.1021/JM0701019 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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