1Q8U

The Catalytic Subunit of cAMP-dependent Protein Kinase in Complex with Rho-kinase Inhibitor H-1152P

Summary for 1Q8U

• Entry DOI: 10.2210/pdb1q8u/pdb
• Related: 1Q8T 1Q8W
• Descriptor: cAMP-dependent protein kinase, alpha-catalytic subunit, cAMP-dependent protein kinase inhibitor, alpha form, (S)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLINE)SULFONYL]-HOMOPIPERAZINE, ... (5 entities in total)
• Functional Keywords: kinase-inhibitor-complex, phosphotransferase/inhibitor, camp, phosphorylation, serine/threonine-protein kinase, atp-binding, pka, rho-kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Bos taurus (cattle); More
• Cellular location: Cytoplasm: P00517
• Total number of polymer chains: 2
• Total formula weight: 43973.06

Authors

Breitenlechner, C.,Gassel, M.,Hidaka, H.,Kinzel, V.,Huber, R.,Engh, R.A.,Bossemeyer, D. (deposition date: 2003-08-22, release date: 2003-12-16, Last modification date: 2011-07-13)

• Primary citation: Breitenlechner, C.,Gassel, M.,Hidaka, H.,Kinzel, V.,Huber, R.,Engh, R.A.,Bossemeyer, D.; Protein kinase A in complex with Rho-kinase inhibitors Y-27632, Fasudil, and H-1152P: structural basis of selectivity.; Structure, 11:1595-1607, 2003; PubMed: 14656443; DOI: 10.1016/j.str.2003.11.002

Experimental method

X-RAY DIFFRACTION (1.9 Å)