2GNI
PKA fivefold mutant model of Rho-kinase with inhibitor Fasudil (HA1077)
Summary for 2GNI
Entry DOI | 10.2210/pdb2gni/pdb |
Related | 1Q8T 1Q8U 1Q8W 2GNF 2GNG 2GNH 2GNJ 2GNL |
Descriptor | cAMP-dependent protein kinase, alpha-catalytic subunit, cAMP-dependent protein kinase inhibitor alpha, 5-(1,4-DIAZEPAN-1-SULFONYL)ISOQUINOLINE, ... (4 entities in total) |
Functional Keywords | pka, mutant, rho-kinase, surrogate, inhibitor, fasudil, ha1077, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Bos taurus (cattle) More |
Cellular location | Cytoplasm: P00517 |
Total number of polymer chains | 2 |
Total formula weight | 43293.24 |
Authors | Bonn, S.,Herrero, S.,Breitenlechner, C.B.,Engh, R.A.,Gassel, M.,Bossemeyer, D. (deposition date: 2006-04-10, release date: 2006-05-23, Last modification date: 2024-04-03) |
Primary citation | Bonn, S.,Herrero, S.,Breitenlechner, C.B.,Erlbruch, A.,Lehmann, W.,Engh, R.A.,Gassel, M.,Bossemeyer, D. Structural analysis of protein kinase A mutants with Rho-kinase inhibitor specificity J.Biol.Chem., 281:24818-24830, 2006 Cited by PubMed: 16699172DOI: 10.1074/jbc.M512374200 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.27 Å) |
Structure validation
Download full validation report![Download](/newweb/media/icons/dl.png)
![Download](/newweb/media/icons/dl.png)